Thermochemotherapy of a human salivary adenocarcinoma cell line

Jun-Ichi Asaumi, Yuzuru Higuchi, Hidenobu Matsuzaki, Jun Murakami, Shoji Kawasaki, Masahiro Kuroda, Koichi Shibuya, Hironobu Konouchi, Miki Hisatomi, Toru Wakasa, Kanji Kishi, Yoshio Hiraki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report on thermochemotherapy in a human salivary gland adenocarcinoma cell line. Hyperthermia reduced the survival rate to 50 and 20% by heating at 43°C for 40 and 60 min, respectively, and is by itself useful in human salivary gland carcinoma treatment. Adriamycin, cisplatin, and mitomycin C can possible be used clinically, while bleomycin and 5-fluorouracil cannot, to treat this carcinoma. The optimal temperature was considered to be 41°C in adriamycin, 42°C in cisplatin, 37°C in mitomycin C, and 42°C in bleomycin in the thermochemotherapy. Thermochemotherapy is a useful tool in the treatment of human salivary gland carcinoma cells, but it is necessary to select the best anticancer drugs and the optimal temperature for optimal success using this treatment.

Original languageEnglish
Pages (from-to)365-369
Number of pages5
JournalOncology Reports
Volume9
Issue number2
Publication statusPublished - Mar 2002

Fingerprint

Salivary Glands
Adenocarcinoma
Mitomycin
Carcinoma
Cell Line
Doxorubicin
Cisplatin
Temperature
Bleomycin
Fluorouracil
Heating
Fever
Pharmaceutical Preparations

Keywords

  • Adenocarcinoma
  • Oral cancer
  • Salivary gland tumor
  • Thermochemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Asaumi, J-I., Higuchi, Y., Matsuzaki, H., Murakami, J., Kawasaki, S., Kuroda, M., ... Hiraki, Y. (2002). Thermochemotherapy of a human salivary adenocarcinoma cell line. Oncology Reports, 9(2), 365-369.

Thermochemotherapy of a human salivary adenocarcinoma cell line. / Asaumi, Jun-Ichi; Higuchi, Yuzuru; Matsuzaki, Hidenobu; Murakami, Jun; Kawasaki, Shoji; Kuroda, Masahiro; Shibuya, Koichi; Konouchi, Hironobu; Hisatomi, Miki; Wakasa, Toru; Kishi, Kanji; Hiraki, Yoshio.

In: Oncology Reports, Vol. 9, No. 2, 03.2002, p. 365-369.

Research output: Contribution to journalArticle

Asaumi, J-I, Higuchi, Y, Matsuzaki, H, Murakami, J, Kawasaki, S, Kuroda, M, Shibuya, K, Konouchi, H, Hisatomi, M, Wakasa, T, Kishi, K & Hiraki, Y 2002, 'Thermochemotherapy of a human salivary adenocarcinoma cell line', Oncology Reports, vol. 9, no. 2, pp. 365-369.
Asaumi, Jun-Ichi ; Higuchi, Yuzuru ; Matsuzaki, Hidenobu ; Murakami, Jun ; Kawasaki, Shoji ; Kuroda, Masahiro ; Shibuya, Koichi ; Konouchi, Hironobu ; Hisatomi, Miki ; Wakasa, Toru ; Kishi, Kanji ; Hiraki, Yoshio. / Thermochemotherapy of a human salivary adenocarcinoma cell line. In: Oncology Reports. 2002 ; Vol. 9, No. 2. pp. 365-369.
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