Thermochemotherapy of a human salivary adenocarcinoma cell line

Jun Ichi Asaumi, Yuzuru Higuchi, Hidenobu Matsuzaki, Jun Murakami, Shoji Kawasaki, Masahiro Kuroda, Koichi Shibuya, Hironobu Konouchi, Miki Hisatomi, Toru Wakasa, Kanji Kishi, Yoshio Hiraki

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3 Citations (Scopus)

Abstract

We report on thermochemotherapy in a human salivary gland adenocarcinoma cell line. Hyperthermia reduced the survival rate to 50 and 20% by heating at 43°C for 40 and 60 min, respectively, and is by itself useful in human salivary gland carcinoma treatment. Adriamycin, cisplatin, and mitomycin C can possible be used clinically, while bleomycin and 5-fluorouracil cannot, to treat this carcinoma. The optimal temperature was considered to be 41°C in adriamycin, 42°C in cisplatin, 37°C in mitomycin C, and 42°C in bleomycin in the thermochemotherapy. Thermochemotherapy is a useful tool in the treatment of human salivary gland carcinoma cells, but it is necessary to select the best anticancer drugs and the optimal temperature for optimal success using this treatment.

Original languageEnglish
Pages (from-to)365-369
Number of pages5
JournalOncology reports
Volume9
Issue number2
Publication statusPublished - Mar 1 2002

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Keywords

  • Adenocarcinoma
  • Oral cancer
  • Salivary gland tumor
  • Thermochemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Asaumi, J. I., Higuchi, Y., Matsuzaki, H., Murakami, J., Kawasaki, S., Kuroda, M., Shibuya, K., Konouchi, H., Hisatomi, M., Wakasa, T., Kishi, K., & Hiraki, Y. (2002). Thermochemotherapy of a human salivary adenocarcinoma cell line. Oncology reports, 9(2), 365-369.