Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome

Yohei Funakoshi, Hiroshi Matsuoka, Katsuya Yamamoto, Kimikazu Yakushijin, Yumiko Inui, Atsuo Okamura, Mai Takeuchi, Hiroshi Yokozaki, Hironobu Minami

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Pure erythroid leukemia (PEL) is an extremely rare disorder characterized by neoplastic proliferation of immature erythroblasts. A 66-year-old man, who had received chemoradiotherapy for hypopharyngeal cancer, was admitted because of pancytopenia. Bone marrow was infiltrated with 81% proerythroblasts positive for CD71 and CD235a. An increased number of macrophages with active hemophagocytosis was also present. Chromosome analysis showed hypodiploid complex abnormalities. The patient died of progressive disease despite induction chemotherapy. Erythroblastic infiltration into the liver and hemophagocytosis in the spleen were found at autopsy. Therapy-related PEL with hemophagocytic syndrome and hepatic infiltration of PEL has never been reported.

Original languageEnglish
Pages (from-to)3031-3035
Number of pages5
JournalInternal Medicine
Volume50
Issue number24
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Hemophagocytic Lymphohistiocytosis
Erythroblasts
Leukemia
Liver
Hypopharyngeal Neoplasms
Pancytopenia
Induction Chemotherapy
Chemoradiotherapy
Autopsy
Therapeutics
Spleen
Chromosomes
Bone Marrow
Macrophages

Keywords

  • Hemophagocytic syndrome
  • Hepatic infiltration
  • Pure erythroid leukemia
  • Therapy-related leukemia

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Funakoshi, Y., Matsuoka, H., Yamamoto, K., Yakushijin, K., Inui, Y., Okamura, A., ... Minami, H. (2011). Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome. Internal Medicine, 50(24), 3031-3035. https://doi.org/10.2169/internalmedicine.50.6168

Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome. / Funakoshi, Yohei; Matsuoka, Hiroshi; Yamamoto, Katsuya; Yakushijin, Kimikazu; Inui, Yumiko; Okamura, Atsuo; Takeuchi, Mai; Yokozaki, Hiroshi; Minami, Hironobu.

In: Internal Medicine, Vol. 50, No. 24, 2011, p. 3031-3035.

Research output: Contribution to journalArticle

Funakoshi, Y, Matsuoka, H, Yamamoto, K, Yakushijin, K, Inui, Y, Okamura, A, Takeuchi, M, Yokozaki, H & Minami, H 2011, 'Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome', Internal Medicine, vol. 50, no. 24, pp. 3031-3035. https://doi.org/10.2169/internalmedicine.50.6168
Funakoshi, Yohei ; Matsuoka, Hiroshi ; Yamamoto, Katsuya ; Yakushijin, Kimikazu ; Inui, Yumiko ; Okamura, Atsuo ; Takeuchi, Mai ; Yokozaki, Hiroshi ; Minami, Hironobu. / Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome. In: Internal Medicine. 2011 ; Vol. 50, No. 24. pp. 3031-3035.
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AU - Takeuchi, Mai

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