Therapy-related myelodysplastic syndrome/acute myeloid leukemia M2 and translocation (8;21)

M. Sakugawa, K. Kojima, K. Kaneda, K. Masuda, Hiromichi Dansako, K. Shinagawa, F. Ishimaru, K. Ikeda, K. Niiya, M. Harada, M. Tanimoto

Research output: Contribution to journalArticle

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Abstract

An 80-year-old woman developed therapy-related myelodysplastic syndrome with translocation (8;21), which was successfully treated with an acute myeloid leukemia oriented chemotherapy. Five years before admission she had received cyclophosphamide, epirubicin, and carboplatin for endometrial cancer. The leukemia cell morphology alerted us to the possibility of the presence of t(8;21) before cytogenetic results were obtained, and AML1/ETO fusion transcript was detected by reverse transcription polymerase chain reaction. She achieved complete remission after one course of idarubicin and cytosine arabinoside. She has remained in complete remission for 6 months. Our experience suggests that recognition of typical morphological features for de novo M2 acute myeloid leukemia with t(8;21) would be important in diagnosis of therapy related myelodysplastic syndrome/acute myeloid leukemia with this translocation, which could respond to an intensive chemotherapy.

Original languageEnglish
Pages (from-to)763-766
Number of pages4
JournalAnnals of Hematology
Volume80
Issue number12
DOIs
Publication statusPublished - 2001

Fingerprint

Myelodysplastic Syndromes
Acute Myeloid Leukemia
Idarubicin
Drug Therapy
Epirubicin
Carboplatin
Cytarabine
Endometrial Neoplasms
Cytogenetics
Cyclophosphamide
Reverse Transcription
Leukemia
Therapeutics
Polymerase Chain Reaction

Keywords

  • Anthracycline
  • Cell morphology
  • Therapy-related acute myeloid leukemia
  • Therapy-related myelodysplastic syndrome
  • Translocation (8;12)

ASJC Scopus subject areas

  • Hematology

Cite this

Sakugawa, M., Kojima, K., Kaneda, K., Masuda, K., Dansako, H., Shinagawa, K., ... Tanimoto, M. (2001). Therapy-related myelodysplastic syndrome/acute myeloid leukemia M2 and translocation (8;21). Annals of Hematology, 80(12), 763-766. https://doi.org/10.1007/s002770100378

Therapy-related myelodysplastic syndrome/acute myeloid leukemia M2 and translocation (8;21). / Sakugawa, M.; Kojima, K.; Kaneda, K.; Masuda, K.; Dansako, Hiromichi; Shinagawa, K.; Ishimaru, F.; Ikeda, K.; Niiya, K.; Harada, M.; Tanimoto, M.

In: Annals of Hematology, Vol. 80, No. 12, 2001, p. 763-766.

Research output: Contribution to journalArticle

Sakugawa, M, Kojima, K, Kaneda, K, Masuda, K, Dansako, H, Shinagawa, K, Ishimaru, F, Ikeda, K, Niiya, K, Harada, M & Tanimoto, M 2001, 'Therapy-related myelodysplastic syndrome/acute myeloid leukemia M2 and translocation (8;21)', Annals of Hematology, vol. 80, no. 12, pp. 763-766. https://doi.org/10.1007/s002770100378
Sakugawa, M. ; Kojima, K. ; Kaneda, K. ; Masuda, K. ; Dansako, Hiromichi ; Shinagawa, K. ; Ishimaru, F. ; Ikeda, K. ; Niiya, K. ; Harada, M. ; Tanimoto, M. / Therapy-related myelodysplastic syndrome/acute myeloid leukemia M2 and translocation (8;21). In: Annals of Hematology. 2001 ; Vol. 80, No. 12. pp. 763-766.
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