Therapeutic strategy for ischemic stroke

Toru Yamashita, Kentaro Deguchi, Yoshihide Sehara, Violeta Lukic-Panin, Hanzhe Zhang, Tatsushi Kamiya, Koji Abe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Possible strategies for treating ischemic stroke include: (1) Neuroprotection: preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia; (2) Stem cell therapy: the repair of broken neuronal networks with newly born neurons in the chronic phase of cerebral ischemia. Firstly, we studied the neuroprotective effect of a calcium channel blocker, azelnidipine, or a by-product of heme degradation, biliverdin, in the ischemic brain. These results revealed both azelnidipine and biliverdin had a neuroprotective effect in the ischemic brain through their anti-oxidative property. Secondly, we investigated the role of granulocyte colony-stimulating factor (G-CSF) by administering G-CSF to rats after cerebral ischemia and found G-CSF plays a critical role in neuroprotection. Lastly, we developed a restorative stroke therapy with a bio-affinitive scaffold, which is able to provide an appropriate environment for newly born neurons. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.

Original languageEnglish
Pages (from-to)707-710
Number of pages4
JournalNeurochemical Research
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Granulocyte Colony-Stimulating Factor
Brain Ischemia
Biliverdine
Neurons
Stroke
Neuroprotective Agents
Brain
Calcium Channel Blockers
Cell- and Tissue-Based Therapy
Stem cells
Heme
Scaffolds
Byproducts
Rats
Repair
Stem Cells
Therapeutics
Apoptosis
Degradation
Neuroprotection

Keywords

  • Cerebral ischemia
  • Free radical
  • G-CSF
  • Neural stem cells
  • Scaffold

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

Cite this

Yamashita, T., Deguchi, K., Sehara, Y., Lukic-Panin, V., Zhang, H., Kamiya, T., & Abe, K. (2009). Therapeutic strategy for ischemic stroke. Neurochemical Research, 34(4), 707-710. https://doi.org/10.1007/s11064-008-9842-2

Therapeutic strategy for ischemic stroke. / Yamashita, Toru; Deguchi, Kentaro; Sehara, Yoshihide; Lukic-Panin, Violeta; Zhang, Hanzhe; Kamiya, Tatsushi; Abe, Koji.

In: Neurochemical Research, Vol. 34, No. 4, 04.2009, p. 707-710.

Research output: Contribution to journalArticle

Yamashita, T, Deguchi, K, Sehara, Y, Lukic-Panin, V, Zhang, H, Kamiya, T & Abe, K 2009, 'Therapeutic strategy for ischemic stroke', Neurochemical Research, vol. 34, no. 4, pp. 707-710. https://doi.org/10.1007/s11064-008-9842-2
Yamashita T, Deguchi K, Sehara Y, Lukic-Panin V, Zhang H, Kamiya T et al. Therapeutic strategy for ischemic stroke. Neurochemical Research. 2009 Apr;34(4):707-710. https://doi.org/10.1007/s11064-008-9842-2
Yamashita, Toru ; Deguchi, Kentaro ; Sehara, Yoshihide ; Lukic-Panin, Violeta ; Zhang, Hanzhe ; Kamiya, Tatsushi ; Abe, Koji. / Therapeutic strategy for ischemic stroke. In: Neurochemical Research. 2009 ; Vol. 34, No. 4. pp. 707-710.
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