Abstract
Possible strategies for treating ischemic stroke include: (1) Neuroprotection: preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia; (2) Stem cell therapy: the repair of broken neuronal networks with newly born neurons in the chronic phase of cerebral ischemia. Firstly, we studied the neuroprotective effect of a calcium channel blocker, azelnidipine, or a by-product of heme degradation, biliverdin, in the ischemic brain. These results revealed both azelnidipine and biliverdin had a neuroprotective effect in the ischemic brain through their anti-oxidative property. Secondly, we investigated the role of granulocyte colony-stimulating factor (G-CSF) by administering G-CSF to rats after cerebral ischemia and found G-CSF plays a critical role in neuroprotection. Lastly, we developed a restorative stroke therapy with a bio-affinitive scaffold, which is able to provide an appropriate environment for newly born neurons. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.
| Original language | English |
|---|---|
| Pages (from-to) | 707-710 |
| Number of pages | 4 |
| Journal | Neurochemical Research |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2009 |
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Keywords
- Cerebral ischemia
- Free radical
- G-CSF
- Neural stem cells
- Scaffold
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Biochemistry
Cite this
Therapeutic strategy for ischemic stroke. / Yamashita, Toru; Deguchi, Kentaro; Sehara, Yoshihide; Lukic-Panin, Violeta; Zhang, Hanzhe; Kamiya, Tatsushi; Abe, Koji.
In: Neurochemical Research, Vol. 34, No. 4, 04.2009, p. 707-710.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic strategy for ischemic stroke
AU - Yamashita, Toru
AU - Deguchi, Kentaro
AU - Sehara, Yoshihide
AU - Lukic-Panin, Violeta
AU - Zhang, Hanzhe
AU - Kamiya, Tatsushi
AU - Abe, Koji
PY - 2009/4
Y1 - 2009/4
N2 - Possible strategies for treating ischemic stroke include: (1) Neuroprotection: preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia; (2) Stem cell therapy: the repair of broken neuronal networks with newly born neurons in the chronic phase of cerebral ischemia. Firstly, we studied the neuroprotective effect of a calcium channel blocker, azelnidipine, or a by-product of heme degradation, biliverdin, in the ischemic brain. These results revealed both azelnidipine and biliverdin had a neuroprotective effect in the ischemic brain through their anti-oxidative property. Secondly, we investigated the role of granulocyte colony-stimulating factor (G-CSF) by administering G-CSF to rats after cerebral ischemia and found G-CSF plays a critical role in neuroprotection. Lastly, we developed a restorative stroke therapy with a bio-affinitive scaffold, which is able to provide an appropriate environment for newly born neurons. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.
AB - Possible strategies for treating ischemic stroke include: (1) Neuroprotection: preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia; (2) Stem cell therapy: the repair of broken neuronal networks with newly born neurons in the chronic phase of cerebral ischemia. Firstly, we studied the neuroprotective effect of a calcium channel blocker, azelnidipine, or a by-product of heme degradation, biliverdin, in the ischemic brain. These results revealed both azelnidipine and biliverdin had a neuroprotective effect in the ischemic brain through their anti-oxidative property. Secondly, we investigated the role of granulocyte colony-stimulating factor (G-CSF) by administering G-CSF to rats after cerebral ischemia and found G-CSF plays a critical role in neuroprotection. Lastly, we developed a restorative stroke therapy with a bio-affinitive scaffold, which is able to provide an appropriate environment for newly born neurons. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.
KW - Cerebral ischemia
KW - Free radical
KW - G-CSF
KW - Neural stem cells
KW - Scaffold
UR - http://www.scopus.com/inward/record.url?scp=62349109263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62349109263&partnerID=8YFLogxK
U2 - 10.1007/s11064-008-9842-2
DO - 10.1007/s11064-008-9842-2
M3 - Article
C2 - 18770029
AN - SCOPUS:62349109263
VL - 34
SP - 707
EP - 710
JO - Neurochemical Research
JF - Neurochemical Research
SN - 0364-3190
IS - 4
ER -