Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury

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186 Citations (Scopus)

Abstract

Development of neuronal and glial cells and their maintenance are under control of neurotrophic factors (NTFs). An exogenous administration of NTFs protects extremely sensitive brain tissue from ischemic damage. On the other hand, it is now known that neural stem cells are present in normal adult brain, and have a potential to compensate and recover neural functions that were lost due to ischemic stroke. These stem cells are also under control of NTFs to differentiate into a certain species of neural cells. Thus, the purpose of this review is to summarize the present understanding of the role of NTFs in normal and ischemic brain and the therapeutic potential of NTF protein itself or gene therapy, and then to summarize the role of NTFs in stem cell differentiation and a possible therapeutic potential with the neural stem cells against ischemic brain injury.

Original languageEnglish
Pages (from-to)1393-1408
Number of pages16
JournalJournal of Cerebral Blood Flow and Metabolism
Volume20
Issue number10
Publication statusPublished - 2000

Fingerprint

Neural Stem Cells
Nerve Growth Factors
Brain Injuries
Therapeutics
Brain
Stem Cells
Neuroglia
Genetic Therapy
Cell Differentiation
Stroke
Maintenance

Keywords

  • Cerebral ischemia
  • Gene therapy
  • Neural stem cell
  • Neurotrophic factor
  • Transplantation

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

Cite this

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AB - Development of neuronal and glial cells and their maintenance are under control of neurotrophic factors (NTFs). An exogenous administration of NTFs protects extremely sensitive brain tissue from ischemic damage. On the other hand, it is now known that neural stem cells are present in normal adult brain, and have a potential to compensate and recover neural functions that were lost due to ischemic stroke. These stem cells are also under control of NTFs to differentiate into a certain species of neural cells. Thus, the purpose of this review is to summarize the present understanding of the role of NTFs in normal and ischemic brain and the therapeutic potential of NTF protein itself or gene therapy, and then to summarize the role of NTFs in stem cell differentiation and a possible therapeutic potential with the neural stem cells against ischemic brain injury.

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