Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury

Research output: Contribution to journalReview article

188 Citations (Scopus)

Abstract

Development of neuronal and glial cells and their maintenance are under control of neurotrophic factors (NTFs). An exogenous administration of NTFs protects extremely sensitive brain tissue from ischemic damage. On the other hand, it is now known that neural stem cells are present in normal adult brain, and have a potential to compensate and recover neural functions that were lost due to ischemic stroke. These stem cells are also under control of NTFs to differentiate into a certain species of neural cells. Thus, the purpose of this review is to summarize the present understanding of the role of NTFs in normal and ischemic brain and the therapeutic potential of NTF protein itself or gene therapy, and then to summarize the role of NTFs in stem cell differentiation and a possible therapeutic potential with the neural stem cells against ischemic brain injury.

Original languageEnglish
Pages (from-to)1393-1408
Number of pages16
JournalJournal of Cerebral Blood Flow and Metabolism
Volume20
Issue number10
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Cerebral ischemia
  • Gene therapy
  • Neural stem cell
  • Neurotrophic factor
  • Transplantation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury'. Together they form a unique fingerprint.

  • Cite this