Therapeutic efficacy of leukocytapheresis in a pregnant woman with severe active ulcerative colitis

Hiroyuki Okada, C. Makidono, R. Takenaka, Sakiko Hiraoka, A. Fujiwara, J. Kato, Yoshiro Kawahara, H. Kawamoto, M. Mizuno, Y. Shiratori

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Leukocytapheresis has recently been used to induce remission in patients with ulcerative colitis (UC) who fail to respond to corticosteroids. We could not find a report in the literature on leukocytapheresis for UC with gestational exacerbation. We have recently encountered this unique condition and report the details here. A 30-year-old Japanese woman with left-sided severe UC was corticosteroid-dependent and had recurrence of the active disease during tapering of corticosteroid. She declined any dose increase and the use of any immunosuppressive agent because she was in the 13th week of pregnancy. Then, concomitant leukocytapheresis was performed without increasing the corticosteroid dose. Recovery was rapid and dramatic. Mucous and bloody stool decreased after the first session, and she had remission 2 weeks later. She underwent a total of four sessions without complications. After 6 weeks, she was discharged from our hospital and underwent maintenance treatment as an outpatient with mesalazine and corticosteroid tapering. Subsequently, she gave birth to a healthy baby girl by an uncomplicated vaginal delivery while keeping the remitted stage of UC.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalDigestion
Volume74
Issue number1
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Leukapheresis
Ulcerative Colitis
Pregnant Women
Adrenal Cortex Hormones
Hospital Maintenance and Engineering
Therapeutics
Mesalamine
Immunosuppressive Agents
Outpatients
Parturition
Recurrence
Pregnancy

Keywords

  • Leukocytapheresis
  • Pregnancy, ulcerative colitis
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Therapeutic efficacy of leukocytapheresis in a pregnant woman with severe active ulcerative colitis. / Okada, Hiroyuki; Makidono, C.; Takenaka, R.; Hiraoka, Sakiko; Fujiwara, A.; Kato, J.; Kawahara, Yoshiro; Kawamoto, H.; Mizuno, M.; Shiratori, Y.

In: Digestion, Vol. 74, No. 1, 11.2006, p. 15-18.

Research output: Contribution to journalArticle

Okada, H, Makidono, C, Takenaka, R, Hiraoka, S, Fujiwara, A, Kato, J, Kawahara, Y, Kawamoto, H, Mizuno, M & Shiratori, Y 2006, 'Therapeutic efficacy of leukocytapheresis in a pregnant woman with severe active ulcerative colitis', Digestion, vol. 74, no. 1, pp. 15-18. https://doi.org/10.1159/000095478
Okada, Hiroyuki ; Makidono, C. ; Takenaka, R. ; Hiraoka, Sakiko ; Fujiwara, A. ; Kato, J. ; Kawahara, Yoshiro ; Kawamoto, H. ; Mizuno, M. ; Shiratori, Y. / Therapeutic efficacy of leukocytapheresis in a pregnant woman with severe active ulcerative colitis. In: Digestion. 2006 ; Vol. 74, No. 1. pp. 15-18.
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