Therapeutic effects of gelatin matrix-embedded IL-12 gene-modified macrophages in a mouse model of residual prostate cancer

K. Tabata, M. Watanabe, K. Naruishi, K. Edamura, T. Satoh, G. Yang, E. Abdel Fattah, J. Wang, A. Goltsov, D. Floryk, S. D. Soni, D. Kadmon, T. C. Thompson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We evaluated the potential use of intraoperative gelatin matrix hemostatic sealant (GMHS; FloSeal; Baxter Healthcare) embedded with macrophages (Mφ) transduced with murine interleukin (IL)-12 recombinant adenoviral vector (G/Mφ/AdmIL-12) for prevention of recurrence of prostate cancer following radical prostatectomy. Application of G/Mφ/AdmIL-12 resulted in significant suppression of tumor growth and spontaneous lung metastases, a statistically significant survival advantage of the G/Mφ/AdmIL-12-treated animals, more efficient trafficking of Mφ to lymph nodes draining from the prostate and generation of systemic natural killer cell activity and tumor-specific cytolytic T lymphocyte responses compared to the controls in a preclinical mouse model of residual prostate cancer. Our data recommend this treatment as a novel adjuvant for prevention of local recurrence of prostate cancer following radical prostatectomy.

Original languageEnglish
Pages (from-to)301-309
Number of pages9
JournalProstate Cancer and Prostatic Diseases
Volume12
Issue number3
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

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    Tabata, K., Watanabe, M., Naruishi, K., Edamura, K., Satoh, T., Yang, G., Abdel Fattah, E., Wang, J., Goltsov, A., Floryk, D., Soni, S. D., Kadmon, D., & Thompson, T. C. (2009). Therapeutic effects of gelatin matrix-embedded IL-12 gene-modified macrophages in a mouse model of residual prostate cancer. Prostate Cancer and Prostatic Diseases, 12(3), 301-309. https://doi.org/10.1038/pcan.2008.57