Therapeutic Approaches Targeting miRNA in Systemic Lupus Erythematosus

Sumie Hiramatsu-Asano, Jun Wada

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications.

Original languageEnglish
Pages (from-to)359-371
Number of pages13
JournalActa medica Okayama
Volume76
Issue number4
DOIs
Publication statusPublished - 2022

Keywords

  • Mirna
  • Mirna targeting therapy
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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