Theranostic Nanoparticles Loaded with Imaging Probes and Rubrocurcumin for Combined Cancer Therapy by Folate Receptor Targeting

Diego Alberti, Nicoletta Protti, Morgane Franck, Rachele Stefania, Silva Bortolussi, Saverio Altieri, Annamaria Deagostino, Silvio Aime, Simonetta Geninatti Crich

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The combination of different therapeutic modalities is a promising option to combat the recurrence of tumors. In this study, polylactic and polyglycolic acid nanoparticles were used for the simultaneous delivery of a boron–curcumin complex (RbCur) and an amphiphilic gadolinium complex into tumor cells with the aim of performing boron and gadolinium neutron capture therapy (NCT) in conjunction with the additional antiproliferative effects of curcumin. Furthermore, the use of Gd complexes allows magnetic resonance imaging (MRI) assessment of the amount of B and Gd internalized by tumor cells. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were targeted to ovarian cancer (IGROV-1) cells through folate receptors, by including in the formulation a PEGylated phospholipid functionalized with the folate moiety. NCT was performed on IGROV-1 cells internalizing 6.4 and 78.6 μg g−1 of 10B and 157Gd, respectively. The synergic action of neutron treatment and curcumin cytotoxicity was shown to result in a significant therapeutic improvement.

Original languageEnglish
Pages (from-to)502-509
Number of pages8
JournalChemMedChem
Volume12
Issue number7
DOIs
Publication statusPublished - Apr 6 2017
Externally publishedYes

Keywords

  • boron neutron capture therapy
  • curcumin
  • gadolinium
  • magnetic resonance imaging
  • oncology
  • poly(lactic-co-glycolic acid)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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