Theranostic application of telomerase-specific oncolytic adenovirus for human cancer

Toshiyoshi Fujiwara, Noriaki Tanaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Replication-selective tumor-specific viruses present a novel approach for treatment of neoplastic disease. Telomerase activation is considered to be a critical step in carcinogenesis and its activity correlates closely with human telomerase reverse transcriptase (hTERT) expression. We constructed an attenuated adenovirus 5 vector (Telomelysin, OBP-301), in which the hTERT promoter element drives expression of E1 genes. We further modified the E3 region of OBP-301 to contain green fluorescent protein (GFP) gene for monitoring viral replication (TelomeScan, OBP-401). When TelomeScan was intratumorally injected into human tumors orthotopically implanted into the rectum in mice, para-aortic lymph node metastasis could be visualized at laparotomy under a three-chip color cooled charged-coupled device camera. This article reviews recent highlights in this rapidly evolving field: cancer therapeutic and cancer diagnostic approaches using the telomerase-specific oncolytic adenoviruses.

Original languageEnglish
Pages (from-to)1913-1922
Number of pages10
JournalNihon rinsho. Japanese journal of clinical medicine
Volume65
Issue number10
Publication statusPublished - Oct 2007

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Human Adenoviruses
Telomerase
Adenoviridae
Neoplasms
Oncogenic Viruses
Viral Genes
Green Fluorescent Proteins
Rectum
Laparotomy
Carcinogenesis
Color
Lymph Nodes
Neoplasm Metastasis
Gene Expression
Equipment and Supplies
Therapeutics
Theranostic Nanomedicine
human TERT protein

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Theranostic application of telomerase-specific oncolytic adenovirus for human cancer. / Fujiwara, Toshiyoshi; Tanaka, Noriaki.

In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 65, No. 10, 10.2007, p. 1913-1922.

Research output: Contribution to journalArticle

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