Abstract
When (-)-epigallocatechin gallate (EGCG), the main constituent of tea polyphenols, was kept in a neutral buffer, it decomposed rapidly to give theasinensin A as the major product. Theasinensin A suppressed the oxacillin resistance of methidllin-resistant Stphylcoccus aureus (MRSA). In the presence of theasinensin A (3.5 × 10-5 M), the minimum inhibitory concentrations (MICs) of oxacillin decreased from 256 or 64 μg/mL to 4 μg/mL for the MRSA strains used. The presence of this compound (3.5 × M-5) also decreased the MIC of other β-lactam (penicillin G, from 32 μg/ mL to 0.125-0.5 μg/mL; ampicillin, from 16-32 μg/ml to 0.5-1 μg/mL) and aminoglycoside (streptomycin, from 4- 16 μg/mL to 0.125 -4 μg/mL) antibiotics for the MRSA strains.
Original language | English |
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Pages (from-to) | 984-989 |
Number of pages | 6 |
Journal | Planta Medica |
Volume | 69 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1 2003 |
Keywords
- Antibiotic resistance
- Camellia sinensis
- Epigallocatechin gallate
- Gallic acid
- MRSA
- Polyphenol
- Theaceae
- Theasinensin A
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry