Abstract
When (-)-epigallocatechin gallate (EGCG), the main constituent of tea polyphenols, was kept in a neutral buffer, it decomposed rapidly to give theasinensin A as the major product. Theasinensin A suppressed the oxacillin resistance of methidllin-resistant Stphylcoccus aureus (MRSA). In the presence of theasinensin A (3.5 × 10-5 M), the minimum inhibitory concentrations (MICs) of oxacillin decreased from 256 or 64 μg/mL to 4 μg/mL for the MRSA strains used. The presence of this compound (3.5 × M-5) also decreased the MIC of other β-lactam (penicillin G, from 32 μg/ mL to 0.125-0.5 μg/mL; ampicillin, from 16-32 μg/ml to 0.5-1 μg/mL) and aminoglycoside (streptomycin, from 4- 16 μg/mL to 0.125 -4 μg/mL) antibiotics for the MRSA strains.
| Original language | English |
|---|---|
| Pages (from-to) | 984-989 |
| Number of pages | 6 |
| Journal | Planta Medica |
| Volume | 69 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2003 |
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Keywords
- Antibiotic resistance
- Camellia sinensis
- Epigallocatechin gallate
- Gallic acid
- MRSA
- Polyphenol
- Theaceae
- Theasinensin A
ASJC Scopus subject areas
- Plant Science
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Theasinensin A, a Tea Polyphenol Formed from (-)-Epigallocatechin Gallate, Suppresses Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus. / Hatano, Tsutomu; Kusuda, Miwako; Hori, Mami; Shiota, Sumiko; Tsuchiya, Tomofusa; Yoshida, Takashi.
In: Planta Medica, Vol. 69, No. 11, 11.2003, p. 984-989.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Theasinensin A, a Tea Polyphenol Formed from (-)-Epigallocatechin Gallate, Suppresses Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus
AU - Hatano, Tsutomu
AU - Kusuda, Miwako
AU - Hori, Mami
AU - Shiota, Sumiko
AU - Tsuchiya, Tomofusa
AU - Yoshida, Takashi
PY - 2003/11
Y1 - 2003/11
N2 - When (-)-epigallocatechin gallate (EGCG), the main constituent of tea polyphenols, was kept in a neutral buffer, it decomposed rapidly to give theasinensin A as the major product. Theasinensin A suppressed the oxacillin resistance of methidllin-resistant Stphylcoccus aureus (MRSA). In the presence of theasinensin A (3.5 × 10-5 M), the minimum inhibitory concentrations (MICs) of oxacillin decreased from 256 or 64 μg/mL to 4 μg/mL for the MRSA strains used. The presence of this compound (3.5 × M-5) also decreased the MIC of other β-lactam (penicillin G, from 32 μg/ mL to 0.125-0.5 μg/mL; ampicillin, from 16-32 μg/ml to 0.5-1 μg/mL) and aminoglycoside (streptomycin, from 4- 16 μg/mL to 0.125 -4 μg/mL) antibiotics for the MRSA strains.
AB - When (-)-epigallocatechin gallate (EGCG), the main constituent of tea polyphenols, was kept in a neutral buffer, it decomposed rapidly to give theasinensin A as the major product. Theasinensin A suppressed the oxacillin resistance of methidllin-resistant Stphylcoccus aureus (MRSA). In the presence of theasinensin A (3.5 × 10-5 M), the minimum inhibitory concentrations (MICs) of oxacillin decreased from 256 or 64 μg/mL to 4 μg/mL for the MRSA strains used. The presence of this compound (3.5 × M-5) also decreased the MIC of other β-lactam (penicillin G, from 32 μg/ mL to 0.125-0.5 μg/mL; ampicillin, from 16-32 μg/ml to 0.5-1 μg/mL) and aminoglycoside (streptomycin, from 4- 16 μg/mL to 0.125 -4 μg/mL) antibiotics for the MRSA strains.
KW - Antibiotic resistance
KW - Camellia sinensis
KW - Epigallocatechin gallate
KW - Gallic acid
KW - MRSA
KW - Polyphenol
KW - Theaceae
KW - Theasinensin A
UR - http://www.scopus.com/inward/record.url?scp=0347950976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347950976&partnerID=8YFLogxK
U2 - 10.1055/s-2003-45142
DO - 10.1055/s-2003-45142
M3 - Article
C2 - 14735433
AN - SCOPUS:0347950976
VL - 69
SP - 984
EP - 989
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 11
ER -