Theasinensin A, a Tea Polyphenol Formed from (-)-Epigallocatechin Gallate, Suppresses Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus

Tsutomu Hatano, Miwako Kusuda, Mami Hori, Sumiko Shiota, Tomofusa Tsuchiya, Takashi Yoshida

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

When (-)-epigallocatechin gallate (EGCG), the main constituent of tea polyphenols, was kept in a neutral buffer, it decomposed rapidly to give theasinensin A as the major product. Theasinensin A suppressed the oxacillin resistance of methidllin-resistant Stphylcoccus aureus (MRSA). In the presence of theasinensin A (3.5 × 10-5 M), the minimum inhibitory concentrations (MICs) of oxacillin decreased from 256 or 64 μg/mL to 4 μg/mL for the MRSA strains used. The presence of this compound (3.5 × M-5) also decreased the MIC of other β-lactam (penicillin G, from 32 μg/ mL to 0.125-0.5 μg/mL; ampicillin, from 16-32 μg/ml to 0.5-1 μg/mL) and aminoglycoside (streptomycin, from 4- 16 μg/mL to 0.125 -4 μg/mL) antibiotics for the MRSA strains.

Original languageEnglish
Pages (from-to)984-989
Number of pages6
JournalPlanta Medica
Volume69
Issue number11
DOIs
Publication statusPublished - Nov 2003

Fingerprint

oxacillin
Methicillin
epigallocatechin
Polyphenols
Tea
Methicillin-Resistant Staphylococcus aureus
Microbial Drug Resistance
minimum inhibitory concentration
antibiotic resistance
tea
Oxacillin
polyphenols
Microbial Sensitivity Tests
lactams
Anti-Bacterial Agents
aminoglycosides
benzylpenicillin
ampicillin
streptomycin
Lactams

Keywords

  • Antibiotic resistance
  • Camellia sinensis
  • Epigallocatechin gallate
  • Gallic acid
  • MRSA
  • Polyphenol
  • Theaceae
  • Theasinensin A

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Theasinensin A, a Tea Polyphenol Formed from (-)-Epigallocatechin Gallate, Suppresses Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus. / Hatano, Tsutomu; Kusuda, Miwako; Hori, Mami; Shiota, Sumiko; Tsuchiya, Tomofusa; Yoshida, Takashi.

In: Planta Medica, Vol. 69, No. 11, 11.2003, p. 984-989.

Research output: Contribution to journalArticle

Hatano, Tsutomu ; Kusuda, Miwako ; Hori, Mami ; Shiota, Sumiko ; Tsuchiya, Tomofusa ; Yoshida, Takashi. / Theasinensin A, a Tea Polyphenol Formed from (-)-Epigallocatechin Gallate, Suppresses Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus. In: Planta Medica. 2003 ; Vol. 69, No. 11. pp. 984-989.
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