The Wittig reaction of benzofuran-2,3-diones (2), cyclic ac-ketoesters was examined. The reaction of 2 having an electron-donating substituent on the aromatic ring with a stable ylide afforded not 3-alkylidene-2(3//)-benzofuranones (4) but 2-alkylidene-3(2//)-benzofuranones (1) with high regioselectivity.
- 3-dione Wittig reaction regioselectivity
- a-ketoester benzofuran-2
ASJC Scopus subject areas
- Drug Discovery