The usefulness of pre-radiofrequency ablation SUV max in 18F-FDG PET/CT to predict the risk of a local recurrence of malignant lung tumors after lung radiofrequency ablation

Sosuke Harada, Shuhei Sato, Etsuji Suzuki, Yoshihiro Okumura, Takao Hiraki, Hideo Gobara, Hidefumi Mimura, Susumu Kanazawa, Mitsumasa Kaji, Toshiyoshi Fujiwara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of the present study was to assess the diagnostic usefulness of Fluorine-18 fluorodeoxyglucose ( 18F-FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of local recurrence of malignant lung tumors by analyzing the pre-radiofrequency ablation (RFA) maximal standardized uptake value (SUV max). We performed a historical cohort study of consecutive malignant lung tumors treated by RFA from January 2007 to May 2008 at Okayama University Hospital. We selected only lung tumors examined by PET/CT within 90 days before RFA and divided them (10 primary and 29 metastatic) into 3 groups according to their tertiles of SUV max. We calculated recurrence odds ratios in the medium group and the high group compared to the low group using multivariate logistic analysis. After we examined the relationship between SUV max and recurrence in a crude model, we adjusted for some factors. Tumors with higher SUV max showed higher recurrence odds ratios (medium group; 1.84, high group; 4.14, respectively). The tumor size also increased the recurrence odds ratio (2.67); we thought this was mainly due to selection bias because we excluded tumors less than 10 mm in diameter. This study demonstrated the pre-RFA SUV max in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors.

Original languageEnglish
Pages (from-to)395-402
Number of pages8
JournalActa medica Okayama
Volume65
Issue number6
Publication statusPublished - Dec 22 2011

Keywords

  • Fluorodeoxyglucose (FDG)
  • Lung
  • Positron emission tomography (PET)
  • Radiofrequency ablation (RFA)
  • Standardized uptake value (SUV)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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