The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats

Rieko Hirunuma; Kazutoyo Endo; Makoto Yanaga; Shuichi Enomoto; Shizuko Ambe; Akira Tanaka; Machiko Tozawa; Fumitoshi Ambe

doi:10.1016/S0969-8043(96)00316-8

The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats

Rieko Hirunuma, Kazutoyo Endo, Makoto Yanaga, Shuichi Enomoto, Shizuko Ambe, Akira Tanaka, Machiko Tozawa, Fumitoshi Ambe

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a ¹⁴N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements. Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re. Ir and Pt in the organs blood and excreta were determined using γ-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.

Original language	English
Pages (from-to)	727-733
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	48
Issue number	6
DOIs	https://doi.org/10.1016/S0969-8043(96)00316-8
Publication status	Published - Jun 1 1997

ASJC Scopus subject areas

Radiation

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Hirunuma, R., Endo, K., Yanaga, M., Enomoto, S., Ambe, S., Tanaka, A., Tozawa, M., & Ambe, F. (1997). The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats. Applied Radiation and Isotopes, 48(6), 727-733. https://doi.org/10.1016/S0969-8043(96)00316-8

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abstract = "The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a 14N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements. Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re. Ir and Pt in the organs blood and excreta were determined using γ-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.",

author = "Rieko Hirunuma and Kazutoyo Endo and Makoto Yanaga and Shuichi Enomoto and Shizuko Ambe and Akira Tanaka and Machiko Tozawa and Fumitoshi Ambe",

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AU - Hirunuma, Rieko

AU - Endo, Kazutoyo

AU - Yanaga, Makoto

AU - Enomoto, Shuichi

AU - Ambe, Shizuko

AU - Tanaka, Akira

AU - Tozawa, Machiko

AU - Ambe, Fumitoshi

PY - 1997/6/1

Y1 - 1997/6/1

N2 - The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a 14N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements. Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re. Ir and Pt in the organs blood and excreta were determined using γ-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.

AB - The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a 14N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements. Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re. Ir and Pt in the organs blood and excreta were determined using γ-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.

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