Abstract
The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a 14N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements. Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re. Ir and Pt in the organs blood and excreta were determined using γ-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.
| Original language | English |
|---|---|
| Pages (from-to) | 727-733 |
| Number of pages | 7 |
| Journal | Applied Radiation and Isotopes |
| Volume | 48 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Radiation
Cite this
The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats. / Hirunuma, Rieko; Endo, Kazutoyo; Yanaga, Makoto; Enomoto, Shuichi; Ambe, Shizuko; Tanaka, Akira; Tozawa, Machiko; Ambe, Fumitoshi.
In: Applied Radiation and Isotopes, Vol. 48, No. 6, 06.1997, p. 727-733.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats
AU - Hirunuma, Rieko
AU - Endo, Kazutoyo
AU - Yanaga, Makoto
AU - Enomoto, Shuichi
AU - Ambe, Shizuko
AU - Tanaka, Akira
AU - Tozawa, Machiko
AU - Ambe, Fumitoshi
PY - 1997/6
Y1 - 1997/6
N2 - The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a 14N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements. Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re. Ir and Pt in the organs blood and excreta were determined using γ-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.
AB - The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a 14N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements. Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re. Ir and Pt in the organs blood and excreta were determined using γ-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031172757&partnerID=8YFLogxK
U2 - 10.1016/S0969-8043(96)00316-8
DO - 10.1016/S0969-8043(96)00316-8
M3 - Article
C2 - 9204524
AN - SCOPUS:0031172757
VL - 48
SP - 727
EP - 733
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 6
ER -