The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats

Rieko Hirunuma, Kazutoyo Endo, Makoto Yanaga, Shuichi Enomoto, Shizuko Ambe, Akira Tanaka, Machiko Tozawa, Fumitoshi Ambe

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a 14N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements. Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re. Ir and Pt in the organs blood and excreta were determined using γ-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.

Original languageEnglish
Pages (from-to)727-733
Number of pages7
JournalApplied Radiation and Isotopes
Volume48
Issue number6
DOIs
Publication statusPublished - Jun 1997
Externally publishedYes

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trace elements
organs
rats
blood
feces
urine
radioactive isotopes
tracers
foils
rays
gold
dosage
acids
spectroscopy

ASJC Scopus subject areas

  • Radiation

Cite this

The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats. / Hirunuma, Rieko; Endo, Kazutoyo; Yanaga, Makoto; Enomoto, Shuichi; Ambe, Shizuko; Tanaka, Akira; Tozawa, Machiko; Ambe, Fumitoshi.

In: Applied Radiation and Isotopes, Vol. 48, No. 6, 06.1997, p. 727-733.

Research output: Contribution to journalArticle

Hirunuma, R, Endo, K, Yanaga, M, Enomoto, S, Ambe, S, Tanaka, A, Tozawa, M & Ambe, F 1997, 'The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats', Applied Radiation and Isotopes, vol. 48, no. 6, pp. 727-733. https://doi.org/10.1016/S0969-8043(96)00316-8
Hirunuma, Rieko ; Endo, Kazutoyo ; Yanaga, Makoto ; Enomoto, Shuichi ; Ambe, Shizuko ; Tanaka, Akira ; Tozawa, Machiko ; Ambe, Fumitoshi. / The use of a multitracer technique for the studies of the uptake and retention of trace elements in rats. In: Applied Radiation and Isotopes. 1997 ; Vol. 48, No. 6. pp. 727-733.
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