The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke

Feifei Wang; Nagamasa Maeda; Takao Yasuhara; Masahiro Kameda; Emi Tsuru; Tatsuyuki Yamashit; Yuan Shen; Masayuki Tsuda; Isao Date; Yusuke Sagara

The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke

Feifei Wang, Nagamasa Maeda, Takao Yasuhara, Masahiro Kameda, Emi Tsuru, Tatsuyuki Yamashit, Yuan Shen, Masayuki Tsuda, Isao Date, Yusuke Sagara

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angio-genesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging thera-peutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.

Original language	English
Pages (from-to)	429-434
Number of pages	6
Journal	Acta medica Okayama
Volume	66
Issue number	6
Publication status	Published - 2012

Keywords

Cell transplantation
Ischemic stroke
Neonatal hypoxic-ischemic brain injury
Stem cells
Umbilical cord blood

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angio-genesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging thera-peutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.",

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T1 - The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke

AU - Wang, Feifei

AU - Maeda, Nagamasa

AU - Yasuhara, Takao

AU - Kameda, Masahiro

AU - Tsuru, Emi

AU - Yamashit, Tatsuyuki

AU - Shen, Yuan

AU - Tsuda, Masayuki

AU - Date, Isao

AU - Sagara, Yusuke

PY - 2012

Y1 - 2012

N2 - Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angio-genesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging thera-peutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.

AB - Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angio-genesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging thera-peutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.

KW - Cell transplantation

KW - Ischemic stroke

KW - Neonatal hypoxic-ischemic brain injury

KW - Stem cells

KW - Umbilical cord blood

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M3 - Review article

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AN - SCOPUS:84873723840

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The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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