TY - JOUR
T1 - The sweet taste receptor, glucose transporters, and the ATP-sensitive K+ (KATP) channel
T2 - sugar sensing for the regulation of energy homeostasis
AU - Yoshida, Ryusuke
AU - Yasumatsu, Keiko
AU - Ninomiya, Yuzo
N1 - Funding Information:
This work was supported by grants JSPS KAKENHI JP18K09507 (RY); JP15K11043 and JP20H03855 (KY); and JP26670810 , JP15H02571 , JP18H02968 , and JP18K19653 (YN) from the Japan Society for the Promotion of Science and a 2018 grant from the Naito Foundation (YN).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/4
Y1 - 2021/4
N2 - Sugar detection in the oral cavity does not solely depend on the TAS1R2 + TAS1R3 sweet receptor. Similar to gut, pancreas, and hypothalamic neurons, in the tongue glucose transporters and ATP-sensitive K+ (KATP) channels are also involved in sugar detection. Among them, the KATP channel is the target for the antiobesity hormone leptin, which inhibits sugar-sensitive cells such as sweet taste cells, pancreatic β-cells, and hypothalamic orexigenic neurons. Sugar signals from the taste organ elicit cephalic-phase insulin release, and those from the gut contribute to sweet preference for caloric sugars. All of these systems are indispensable for maintaining energy homeostasis. Thus, an exquisite system for sugar detection/signaling to regulate energy homeostasis exists in our body.
AB - Sugar detection in the oral cavity does not solely depend on the TAS1R2 + TAS1R3 sweet receptor. Similar to gut, pancreas, and hypothalamic neurons, in the tongue glucose transporters and ATP-sensitive K+ (KATP) channels are also involved in sugar detection. Among them, the KATP channel is the target for the antiobesity hormone leptin, which inhibits sugar-sensitive cells such as sweet taste cells, pancreatic β-cells, and hypothalamic orexigenic neurons. Sugar signals from the taste organ elicit cephalic-phase insulin release, and those from the gut contribute to sweet preference for caloric sugars. All of these systems are indispensable for maintaining energy homeostasis. Thus, an exquisite system for sugar detection/signaling to regulate energy homeostasis exists in our body.
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U2 - 10.1016/j.cophys.2021.01.009
DO - 10.1016/j.cophys.2021.01.009
M3 - Review article
AN - SCOPUS:85100050390
VL - 20
SP - 57
EP - 63
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
SN - 2468-8681
ER -