The superiority of an extracellular fluid solution over Euro-collins’ solution for pulmonary preservation

F. Yamazaki, H. Yokomise, S. H. Keshavjee, S. Miyoshi, P. F. Cardoso, A. S. Slutsky, G. A. Patterson, G. A. Patterson

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Limited donor supply is the major factor restricting the application of lung transplantation. A uniformly reliable method of lung preservation would improve donor organ availability. At present, Euro-Collins’ solution, an intracellular fluid-type solution, is most widely used in organ preservation. However, we have previously shown that initial pulmonary flush with an extracellular-type solution (low-potassium dextran solution [LPD]) provided better pulmonary preservation than Euro-C. In the present study, we used an in vitro— ventilated, blood-perfused rabbit lung model to examine whether the mechanism for this improvement was related to the effect of LPD during pulmonary flush or its effect during storage. Rabbit lungs were harvested and stored after pulmonary flush with different solutions (group 1: 400 ml of LPD; group 2: 400 ml of Euro-C; group 4: 300 ml of Euro-C followed by 100 ml of LPD; n=5 in each group). The lungs were then preserved at 10°C for 18 hr and reperfused with fresh venous blood. After 10 min of reperfusion, lungs in group 1 showed the highest P02 (group 1: 124.4±7.7 mmHg; group 2: 46.2±9.4 mmHg P

Original languageEnglish
Pages (from-to)690-694
Number of pages5
JournalTransplantation
Volume49
Issue number4
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Extracellular Fluid
Lung
Dextrans
Potassium
Intracellular Fluid
Tissue Donors
Rabbits
Organ Preservation
Euro-Collins' solution
Lung Transplantation
Reperfusion

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Yamazaki, F., Yokomise, H., Keshavjee, S. H., Miyoshi, S., Cardoso, P. F., Slutsky, A. S., ... Patterson, G. A. (1990). The superiority of an extracellular fluid solution over Euro-collins’ solution for pulmonary preservation. Transplantation, 49(4), 690-694.

The superiority of an extracellular fluid solution over Euro-collins’ solution for pulmonary preservation. / Yamazaki, F.; Yokomise, H.; Keshavjee, S. H.; Miyoshi, S.; Cardoso, P. F.; Slutsky, A. S.; Patterson, G. A.; Patterson, G. A.

In: Transplantation, Vol. 49, No. 4, 1990, p. 690-694.

Research output: Contribution to journalArticle

Yamazaki, F, Yokomise, H, Keshavjee, SH, Miyoshi, S, Cardoso, PF, Slutsky, AS, Patterson, GA & Patterson, GA 1990, 'The superiority of an extracellular fluid solution over Euro-collins’ solution for pulmonary preservation', Transplantation, vol. 49, no. 4, pp. 690-694.
Yamazaki F, Yokomise H, Keshavjee SH, Miyoshi S, Cardoso PF, Slutsky AS et al. The superiority of an extracellular fluid solution over Euro-collins’ solution for pulmonary preservation. Transplantation. 1990;49(4):690-694.
Yamazaki, F. ; Yokomise, H. ; Keshavjee, S. H. ; Miyoshi, S. ; Cardoso, P. F. ; Slutsky, A. S. ; Patterson, G. A. ; Patterson, G. A. / The superiority of an extracellular fluid solution over Euro-collins’ solution for pulmonary preservation. In: Transplantation. 1990 ; Vol. 49, No. 4. pp. 690-694.
@article{3125ebb7ab2d42249dffc99559f9d8a1,
title = "The superiority of an extracellular fluid solution over Euro-collins’ solution for pulmonary preservation",
abstract = "Limited donor supply is the major factor restricting the application of lung transplantation. A uniformly reliable method of lung preservation would improve donor organ availability. At present, Euro-Collins’ solution, an intracellular fluid-type solution, is most widely used in organ preservation. However, we have previously shown that initial pulmonary flush with an extracellular-type solution (low-potassium dextran solution [LPD]) provided better pulmonary preservation than Euro-C. In the present study, we used an in vitro— ventilated, blood-perfused rabbit lung model to examine whether the mechanism for this improvement was related to the effect of LPD during pulmonary flush or its effect during storage. Rabbit lungs were harvested and stored after pulmonary flush with different solutions (group 1: 400 ml of LPD; group 2: 400 ml of Euro-C; group 4: 300 ml of Euro-C followed by 100 ml of LPD; n=5 in each group). The lungs were then preserved at 10°C for 18 hr and reperfused with fresh venous blood. After 10 min of reperfusion, lungs in group 1 showed the highest P02 (group 1: 124.4±7.7 mmHg; group 2: 46.2±9.4 mmHg P",
author = "F. Yamazaki and H. Yokomise and Keshavjee, {S. H.} and S. Miyoshi and Cardoso, {P. F.} and Slutsky, {A. S.} and Patterson, {G. A.} and Patterson, {G. A.}",
year = "1990",
language = "English",
volume = "49",
pages = "690--694",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - The superiority of an extracellular fluid solution over Euro-collins’ solution for pulmonary preservation

AU - Yamazaki, F.

AU - Yokomise, H.

AU - Keshavjee, S. H.

AU - Miyoshi, S.

AU - Cardoso, P. F.

AU - Slutsky, A. S.

AU - Patterson, G. A.

AU - Patterson, G. A.

PY - 1990

Y1 - 1990

N2 - Limited donor supply is the major factor restricting the application of lung transplantation. A uniformly reliable method of lung preservation would improve donor organ availability. At present, Euro-Collins’ solution, an intracellular fluid-type solution, is most widely used in organ preservation. However, we have previously shown that initial pulmonary flush with an extracellular-type solution (low-potassium dextran solution [LPD]) provided better pulmonary preservation than Euro-C. In the present study, we used an in vitro— ventilated, blood-perfused rabbit lung model to examine whether the mechanism for this improvement was related to the effect of LPD during pulmonary flush or its effect during storage. Rabbit lungs were harvested and stored after pulmonary flush with different solutions (group 1: 400 ml of LPD; group 2: 400 ml of Euro-C; group 4: 300 ml of Euro-C followed by 100 ml of LPD; n=5 in each group). The lungs were then preserved at 10°C for 18 hr and reperfused with fresh venous blood. After 10 min of reperfusion, lungs in group 1 showed the highest P02 (group 1: 124.4±7.7 mmHg; group 2: 46.2±9.4 mmHg P

AB - Limited donor supply is the major factor restricting the application of lung transplantation. A uniformly reliable method of lung preservation would improve donor organ availability. At present, Euro-Collins’ solution, an intracellular fluid-type solution, is most widely used in organ preservation. However, we have previously shown that initial pulmonary flush with an extracellular-type solution (low-potassium dextran solution [LPD]) provided better pulmonary preservation than Euro-C. In the present study, we used an in vitro— ventilated, blood-perfused rabbit lung model to examine whether the mechanism for this improvement was related to the effect of LPD during pulmonary flush or its effect during storage. Rabbit lungs were harvested and stored after pulmonary flush with different solutions (group 1: 400 ml of LPD; group 2: 400 ml of Euro-C; group 4: 300 ml of Euro-C followed by 100 ml of LPD; n=5 in each group). The lungs were then preserved at 10°C for 18 hr and reperfused with fresh venous blood. After 10 min of reperfusion, lungs in group 1 showed the highest P02 (group 1: 124.4±7.7 mmHg; group 2: 46.2±9.4 mmHg P

UR - http://www.scopus.com/inward/record.url?scp=0025233878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025233878&partnerID=8YFLogxK

M3 - Article

C2 - 1691536

AN - SCOPUS:0025233878

VL - 49

SP - 690

EP - 694

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 4

ER -