The somatostatin SST2A receptor in the rat trigeminal ganglion

H. Ichikawa, S. Schulz, V. Höllt, T. Sugimoto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Immunohistochemistry for the somatostatin sst2A receptor was performed on the rat trigeminal ganglion to know its function in the trigeminal nervous system. The immunoreactivity was detected in 9.4% of primary sensory neurons in the ganglion. These neurons were small to medium-sized (range=106.5-1123.2 μm2; mean±S.D.=506.3±213.2 μm2) and predominantly located in the rostromedial part of the ophthalmo-maxillary division. They were also immunoreactive for calcitonin gene-related peptide and the vanilloid receptor subtype 1. In addition, 13.7% of trigeminal neurons which were retrogradely traced with fluorogold from the nasal mucosa exhibited sst2A receptor-immmunoreactivity. Trigeminal neurons which innervated the facial skin and tooth pulp were devoid of the immunoreactivity. In the brainstem trigeminal sensory nuclear complex, both the neuronal cell body and the neuropil exhibited sst2A receptor-immunoreactivity in the superficial medullary dorsal horn. The present study indicates that sst2A receptor-immunoreactive trigeminal nociceptors innervate the nasal mucosa. They may project to the superficial laminae of the medullary dorsal horn.

Original languageEnglish
Pages (from-to)807-813
Number of pages7
JournalNeuroscience
Volume120
Issue number3
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Trigeminal Ganglion
Somatostatin Receptors
Nasal Mucosa
Neurons
Calcitonin Gene-Related Peptide Receptors
Trigeminal Nuclei
Nociceptors
Neuropil
Sensory Receptor Cells
Ganglia
Nervous System
Brain Stem
Tooth
Immunohistochemistry
Skin
somatostatin receptor sst2A
Spinal Cord Dorsal Horn

Keywords

  • Calcitonin gene-related peptide
  • Immunohistochemistry
  • Medullary dorsal horn
  • sst2A receptor
  • Trigeminal ganglion
  • TRPV1 receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ichikawa, H., Schulz, S., Höllt, V., & Sugimoto, T. (2003). The somatostatin SST2A receptor in the rat trigeminal ganglion. Neuroscience, 120(3), 807-813. https://doi.org/10.1016/S0306-4522(03)00364-6

The somatostatin SST2A receptor in the rat trigeminal ganglion. / Ichikawa, H.; Schulz, S.; Höllt, V.; Sugimoto, T.

In: Neuroscience, Vol. 120, No. 3, 01.09.2003, p. 807-813.

Research output: Contribution to journalArticle

Ichikawa, H, Schulz, S, Höllt, V & Sugimoto, T 2003, 'The somatostatin SST2A receptor in the rat trigeminal ganglion', Neuroscience, vol. 120, no. 3, pp. 807-813. https://doi.org/10.1016/S0306-4522(03)00364-6
Ichikawa, H. ; Schulz, S. ; Höllt, V. ; Sugimoto, T. / The somatostatin SST2A receptor in the rat trigeminal ganglion. In: Neuroscience. 2003 ; Vol. 120, No. 3. pp. 807-813.
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