The significance of atherogenic indices in patients on hemodialysis

Kazuhiro Oishi, Yoshio Nagake, Hiroko Yamasaki, Shinji Fukuda, Haruo Ichikawa, Kosuke Ota, Hirofumi Makino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Atherosclerotic diseases (ASD) are the major cause of mortality and morbidity in patients on hemodialysis (HD). To evaluate the significance and usefulness of atherogenic indices, we examined lipoprotein(a) (Lp(a)), remnant-like particles cholesterol (RLP.C), homocysteine (Hcy), cardiac troponin T (TnT), and ankle-arm blood pressure index (AABI) in 114 patients on HD (male 79, female 35; age 62.1 ± 1.3 years). As a result, serum cardiac TnT and AABI levels in patients with diabetes mellitus (DM) (n = 33) were significantly higher than those in patients without DM (n = 81). In patients with cerebrovascular diseases (CVD), serum levels of both RLP.C and Hey, and AABI levels were significantly higher than those in patients without CVD. In patients with coronary artery diseases (CAD), serum cardiac TnT and AABI levels were significantly higher than those in patients without CAD. In patients with peripheral vascular diseases (PVD), serum levels of both Hey and cardiac TnT were significantly higher than those in patients without PVD. Multiple regression analysis did show that the presence of DM, serum Hcy levels and age were independent factors associated with ASD: ASD = -0.348 + 0.426 x DM (scored: 0, absence; 1, presence) + 0.005 x Hcy (nmol/ml) + 0.010 x Age (years) (p < 0.001). In conclusion, the presence of DM and advanced age are major determinants for atherosclerosis. In addition, serum Hcy levels are independent risk factors for atherosclerosis irrespective of the absence of DM. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalAmerican Journal of Nephrology
Volume20
Issue number2
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Ankle-arm blood pressure index
  • Atherosclerosis
  • Cholesterol
  • Hemodialysis
  • Homocysteine cardiac troponin T
  • Lipoprotein(a)
  • Remnant-like particles

ASJC Scopus subject areas

  • Nephrology

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    Oishi, K., Nagake, Y., Yamasaki, H., Fukuda, S., Ichikawa, H., Ota, K., & Makino, H. (2000). The significance of atherogenic indices in patients on hemodialysis. American Journal of Nephrology, 20(2), 107-115. https://doi.org/10.1159/000013566