Abstract
Atherosclerotic diseases (ASD) are the major cause of mortality and morbidity in patients on hemodialysis (HD). To evaluate the significance and usefulness of atherogenic indices, we examined lipoprotein(a) (Lp(a)), remnant-like particles cholesterol (RLP.C), homocysteine (Hcy), cardiac troponin T (TnT), and ankle-arm blood pressure index (AABI) in 114 patients on HD (male 79, female 35; age 62.1 ± 1.3 years). As a result, serum cardiac TnT and AABI levels in patients with diabetes mellitus (DM) (n = 33) were significantly higher than those in patients without DM (n = 81). In patients with cerebrovascular diseases (CVD), serum levels of both RLP.C and Hey, and AABI levels were significantly higher than those in patients without CVD. In patients with coronary artery diseases (CAD), serum cardiac TnT and AABI levels were significantly higher than those in patients without CAD. In patients with peripheral vascular diseases (PVD), serum levels of both Hey and cardiac TnT were significantly higher than those in patients without PVD. Multiple regression analysis did show that the presence of DM, serum Hcy levels and age were independent factors associated with ASD: ASD = -0.348 + 0.426 x DM (scored: 0, absence; 1, presence) + 0.005 x Hcy (nmol/ml) + 0.010 x Age (years) (p < 0.001). In conclusion, the presence of DM and advanced age are major determinants for atherosclerosis. In addition, serum Hcy levels are independent risk factors for atherosclerosis irrespective of the absence of DM. Copyright (C) 2000 S. Karger AG, Basel.
| Original language | English |
|---|---|
| Pages (from-to) | 107-115 |
| Number of pages | 9 |
| Journal | American Journal of Nephrology |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2000 |
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Keywords
- Ankle-arm blood pressure index
- Atherosclerosis
- Cholesterol
- Hemodialysis
- Homocysteine cardiac troponin T
- Lipoprotein(a)
- Remnant-like particles
ASJC Scopus subject areas
- Nephrology
Cite this
The significance of atherogenic indices in patients on hemodialysis. / Oishi, Kazuhiro; Nagake, Yoshio; Yamasaki, Hiroko; Fukuda, Shinji; Ichikawa, Haruo; Ota, Kosuke; Makino, Hirofumi.
In: American Journal of Nephrology, Vol. 20, No. 2, 01.01.2000, p. 107-115.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The significance of atherogenic indices in patients on hemodialysis
AU - Oishi, Kazuhiro
AU - Nagake, Yoshio
AU - Yamasaki, Hiroko
AU - Fukuda, Shinji
AU - Ichikawa, Haruo
AU - Ota, Kosuke
AU - Makino, Hirofumi
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Atherosclerotic diseases (ASD) are the major cause of mortality and morbidity in patients on hemodialysis (HD). To evaluate the significance and usefulness of atherogenic indices, we examined lipoprotein(a) (Lp(a)), remnant-like particles cholesterol (RLP.C), homocysteine (Hcy), cardiac troponin T (TnT), and ankle-arm blood pressure index (AABI) in 114 patients on HD (male 79, female 35; age 62.1 ± 1.3 years). As a result, serum cardiac TnT and AABI levels in patients with diabetes mellitus (DM) (n = 33) were significantly higher than those in patients without DM (n = 81). In patients with cerebrovascular diseases (CVD), serum levels of both RLP.C and Hey, and AABI levels were significantly higher than those in patients without CVD. In patients with coronary artery diseases (CAD), serum cardiac TnT and AABI levels were significantly higher than those in patients without CAD. In patients with peripheral vascular diseases (PVD), serum levels of both Hey and cardiac TnT were significantly higher than those in patients without PVD. Multiple regression analysis did show that the presence of DM, serum Hcy levels and age were independent factors associated with ASD: ASD = -0.348 + 0.426 x DM (scored: 0, absence; 1, presence) + 0.005 x Hcy (nmol/ml) + 0.010 x Age (years) (p < 0.001). In conclusion, the presence of DM and advanced age are major determinants for atherosclerosis. In addition, serum Hcy levels are independent risk factors for atherosclerosis irrespective of the absence of DM. Copyright (C) 2000 S. Karger AG, Basel.
AB - Atherosclerotic diseases (ASD) are the major cause of mortality and morbidity in patients on hemodialysis (HD). To evaluate the significance and usefulness of atherogenic indices, we examined lipoprotein(a) (Lp(a)), remnant-like particles cholesterol (RLP.C), homocysteine (Hcy), cardiac troponin T (TnT), and ankle-arm blood pressure index (AABI) in 114 patients on HD (male 79, female 35; age 62.1 ± 1.3 years). As a result, serum cardiac TnT and AABI levels in patients with diabetes mellitus (DM) (n = 33) were significantly higher than those in patients without DM (n = 81). In patients with cerebrovascular diseases (CVD), serum levels of both RLP.C and Hey, and AABI levels were significantly higher than those in patients without CVD. In patients with coronary artery diseases (CAD), serum cardiac TnT and AABI levels were significantly higher than those in patients without CAD. In patients with peripheral vascular diseases (PVD), serum levels of both Hey and cardiac TnT were significantly higher than those in patients without PVD. Multiple regression analysis did show that the presence of DM, serum Hcy levels and age were independent factors associated with ASD: ASD = -0.348 + 0.426 x DM (scored: 0, absence; 1, presence) + 0.005 x Hcy (nmol/ml) + 0.010 x Age (years) (p < 0.001). In conclusion, the presence of DM and advanced age are major determinants for atherosclerosis. In addition, serum Hcy levels are independent risk factors for atherosclerosis irrespective of the absence of DM. Copyright (C) 2000 S. Karger AG, Basel.
KW - Ankle-arm blood pressure index
KW - Atherosclerosis
KW - Cholesterol
KW - Hemodialysis
KW - Homocysteine cardiac troponin T
KW - Lipoprotein(a)
KW - Remnant-like particles
UR - http://www.scopus.com/inward/record.url?scp=0034006086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034006086&partnerID=8YFLogxK
U2 - 10.1159/000013566
DO - 10.1159/000013566
M3 - Article
C2 - 10773610
AN - SCOPUS:0034006086
VL - 20
SP - 107
EP - 115
JO - American Journal of Nephrology
JF - American Journal of Nephrology
SN - 0250-8095
IS - 2
ER -