The serum oxidative/anti-oxidative stress balance becomes dysregulated in patients with non-alcoholic steatohepatitis associated with hepatocellular carcinoma

Yasuyuki Shimomura, Akinobu Takaki, Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Takayuki Maruyama, Naofumi Tamaki, Daisuke Uchida, Hideki Ohnishi, Kenji Kuwaki, Shinichiro Nakamura, Kazuhiro Nouso, Yasuhiro Miyake, Kazuko Koike, Takaaki Tomofuji, Manabu Morita, Kazuhide Yamamoto, Hiroyuki Okada

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective Oxidative stress is associated with the progression of chronic liver disease. Non-alcoholic fatty liver disease (NAFLD) is also an oxidative stress-related disease. However, the oxidative/anti-oxidative balance has not been fully characterized in NAFLD. The objective of the present study was to investigate the balance between oxidative stress and the anti-oxidative activity in NAFLD, including non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC). Patients We recruited 69 patients with histologically proven NAFLD without HCC (NAFLD; n=58), and with NASH-related HCC (NASH-HCC; n=11). The 58 NAFLD patients included patients with non-alcoholic fatty liver (NAFL; n=14) and NASH (n=44). Methods The serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY) were determined and then used to calculate the oxidative index. The correlations among such factors as ROM, OXY, oxidative index, and clinical characteristics were investigated. Results In NAFLD, ROM positively correlated with the body mass index (BMI), hemoglobin A1c (HbA1c), C-reactive protein (CRP), and the histological grade or inflammatory scores, while only high HbA1c and CRP levels were significant factors that correlated with a higher ROM according to a multivariate analysis. OXY positively correlated with the platelet counts, albumin, and creatinine levels, while negatively correlating with age. However, it improved after treatment intervention. The oxidative index positively correlated with BMI, CRP, and HbA1c. The NASH-HCC patients exhibited a lower OXY than the NASH patients, probably due to the effects of aging. Conclusion Oxidative stress correlated with the levels of NASH activity markers, while the anti-oxidative function was preserved in younger patients as well as in patients with a well-preserved liver function. The NASH-HCC patients tended to be older and exhibited a diminished anti-oxidative function.

Original languageEnglish
Pages (from-to)243-251
Number of pages9
JournalInternal Medicine
Volume56
Issue number3
DOIs
Publication statusPublished - 2017

Fingerprint

Fatty Liver
Hepatocellular Carcinoma
Oxidative Stress
Serum
Hemoglobin C
C-Reactive Protein
Oxygen
Body Mass Index
Non-alcoholic Fatty Liver Disease
Platelet Count
Liver Diseases
Albumins
Creatinine
Hemoglobins
Chronic Disease
Multivariate Analysis
Liver

Keywords

  • Antioxidant
  • Non-alcoholic steatohepatitis
  • Oxidative stress

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The serum oxidative/anti-oxidative stress balance becomes dysregulated in patients with non-alcoholic steatohepatitis associated with hepatocellular carcinoma. / Shimomura, Yasuyuki; Takaki, Akinobu; Wada, Nozomu; Yasunaka, Tetsuya; Ikeda, Fusao; Maruyama, Takayuki; Tamaki, Naofumi; Uchida, Daisuke; Ohnishi, Hideki; Kuwaki, Kenji; Nakamura, Shinichiro; Nouso, Kazuhiro; Miyake, Yasuhiro; Koike, Kazuko; Tomofuji, Takaaki; Morita, Manabu; Yamamoto, Kazuhide; Okada, Hiroyuki.

In: Internal Medicine, Vol. 56, No. 3, 2017, p. 243-251.

Research output: Contribution to journalArticle

Shimomura, Yasuyuki ; Takaki, Akinobu ; Wada, Nozomu ; Yasunaka, Tetsuya ; Ikeda, Fusao ; Maruyama, Takayuki ; Tamaki, Naofumi ; Uchida, Daisuke ; Ohnishi, Hideki ; Kuwaki, Kenji ; Nakamura, Shinichiro ; Nouso, Kazuhiro ; Miyake, Yasuhiro ; Koike, Kazuko ; Tomofuji, Takaaki ; Morita, Manabu ; Yamamoto, Kazuhide ; Okada, Hiroyuki. / The serum oxidative/anti-oxidative stress balance becomes dysregulated in patients with non-alcoholic steatohepatitis associated with hepatocellular carcinoma. In: Internal Medicine. 2017 ; Vol. 56, No. 3. pp. 243-251.
@article{e3fe78cf54b3445ca7714583f113162c,
title = "The serum oxidative/anti-oxidative stress balance becomes dysregulated in patients with non-alcoholic steatohepatitis associated with hepatocellular carcinoma",
abstract = "Objective Oxidative stress is associated with the progression of chronic liver disease. Non-alcoholic fatty liver disease (NAFLD) is also an oxidative stress-related disease. However, the oxidative/anti-oxidative balance has not been fully characterized in NAFLD. The objective of the present study was to investigate the balance between oxidative stress and the anti-oxidative activity in NAFLD, including non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC). Patients We recruited 69 patients with histologically proven NAFLD without HCC (NAFLD; n=58), and with NASH-related HCC (NASH-HCC; n=11). The 58 NAFLD patients included patients with non-alcoholic fatty liver (NAFL; n=14) and NASH (n=44). Methods The serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY) were determined and then used to calculate the oxidative index. The correlations among such factors as ROM, OXY, oxidative index, and clinical characteristics were investigated. Results In NAFLD, ROM positively correlated with the body mass index (BMI), hemoglobin A1c (HbA1c), C-reactive protein (CRP), and the histological grade or inflammatory scores, while only high HbA1c and CRP levels were significant factors that correlated with a higher ROM according to a multivariate analysis. OXY positively correlated with the platelet counts, albumin, and creatinine levels, while negatively correlating with age. However, it improved after treatment intervention. The oxidative index positively correlated with BMI, CRP, and HbA1c. The NASH-HCC patients exhibited a lower OXY than the NASH patients, probably due to the effects of aging. Conclusion Oxidative stress correlated with the levels of NASH activity markers, while the anti-oxidative function was preserved in younger patients as well as in patients with a well-preserved liver function. The NASH-HCC patients tended to be older and exhibited a diminished anti-oxidative function.",
keywords = "Antioxidant, Non-alcoholic steatohepatitis, Oxidative stress",
author = "Yasuyuki Shimomura and Akinobu Takaki and Nozomu Wada and Tetsuya Yasunaka and Fusao Ikeda and Takayuki Maruyama and Naofumi Tamaki and Daisuke Uchida and Hideki Ohnishi and Kenji Kuwaki and Shinichiro Nakamura and Kazuhiro Nouso and Yasuhiro Miyake and Kazuko Koike and Takaaki Tomofuji and Manabu Morita and Kazuhide Yamamoto and Hiroyuki Okada",
year = "2017",
doi = "10.2169/internalmedicine.56.7002",
language = "English",
volume = "56",
pages = "243--251",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "3",

}

TY - JOUR

T1 - The serum oxidative/anti-oxidative stress balance becomes dysregulated in patients with non-alcoholic steatohepatitis associated with hepatocellular carcinoma

AU - Shimomura, Yasuyuki

AU - Takaki, Akinobu

AU - Wada, Nozomu

AU - Yasunaka, Tetsuya

AU - Ikeda, Fusao

AU - Maruyama, Takayuki

AU - Tamaki, Naofumi

AU - Uchida, Daisuke

AU - Ohnishi, Hideki

AU - Kuwaki, Kenji

AU - Nakamura, Shinichiro

AU - Nouso, Kazuhiro

AU - Miyake, Yasuhiro

AU - Koike, Kazuko

AU - Tomofuji, Takaaki

AU - Morita, Manabu

AU - Yamamoto, Kazuhide

AU - Okada, Hiroyuki

PY - 2017

Y1 - 2017

N2 - Objective Oxidative stress is associated with the progression of chronic liver disease. Non-alcoholic fatty liver disease (NAFLD) is also an oxidative stress-related disease. However, the oxidative/anti-oxidative balance has not been fully characterized in NAFLD. The objective of the present study was to investigate the balance between oxidative stress and the anti-oxidative activity in NAFLD, including non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC). Patients We recruited 69 patients with histologically proven NAFLD without HCC (NAFLD; n=58), and with NASH-related HCC (NASH-HCC; n=11). The 58 NAFLD patients included patients with non-alcoholic fatty liver (NAFL; n=14) and NASH (n=44). Methods The serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY) were determined and then used to calculate the oxidative index. The correlations among such factors as ROM, OXY, oxidative index, and clinical characteristics were investigated. Results In NAFLD, ROM positively correlated with the body mass index (BMI), hemoglobin A1c (HbA1c), C-reactive protein (CRP), and the histological grade or inflammatory scores, while only high HbA1c and CRP levels were significant factors that correlated with a higher ROM according to a multivariate analysis. OXY positively correlated with the platelet counts, albumin, and creatinine levels, while negatively correlating with age. However, it improved after treatment intervention. The oxidative index positively correlated with BMI, CRP, and HbA1c. The NASH-HCC patients exhibited a lower OXY than the NASH patients, probably due to the effects of aging. Conclusion Oxidative stress correlated with the levels of NASH activity markers, while the anti-oxidative function was preserved in younger patients as well as in patients with a well-preserved liver function. The NASH-HCC patients tended to be older and exhibited a diminished anti-oxidative function.

AB - Objective Oxidative stress is associated with the progression of chronic liver disease. Non-alcoholic fatty liver disease (NAFLD) is also an oxidative stress-related disease. However, the oxidative/anti-oxidative balance has not been fully characterized in NAFLD. The objective of the present study was to investigate the balance between oxidative stress and the anti-oxidative activity in NAFLD, including non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC). Patients We recruited 69 patients with histologically proven NAFLD without HCC (NAFLD; n=58), and with NASH-related HCC (NASH-HCC; n=11). The 58 NAFLD patients included patients with non-alcoholic fatty liver (NAFL; n=14) and NASH (n=44). Methods The serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY) were determined and then used to calculate the oxidative index. The correlations among such factors as ROM, OXY, oxidative index, and clinical characteristics were investigated. Results In NAFLD, ROM positively correlated with the body mass index (BMI), hemoglobin A1c (HbA1c), C-reactive protein (CRP), and the histological grade or inflammatory scores, while only high HbA1c and CRP levels were significant factors that correlated with a higher ROM according to a multivariate analysis. OXY positively correlated with the platelet counts, albumin, and creatinine levels, while negatively correlating with age. However, it improved after treatment intervention. The oxidative index positively correlated with BMI, CRP, and HbA1c. The NASH-HCC patients exhibited a lower OXY than the NASH patients, probably due to the effects of aging. Conclusion Oxidative stress correlated with the levels of NASH activity markers, while the anti-oxidative function was preserved in younger patients as well as in patients with a well-preserved liver function. The NASH-HCC patients tended to be older and exhibited a diminished anti-oxidative function.

KW - Antioxidant

KW - Non-alcoholic steatohepatitis

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=85011422328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011422328&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.56.7002

DO - 10.2169/internalmedicine.56.7002

M3 - Article

VL - 56

SP - 243

EP - 251

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 3

ER -