The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

Keiichiro Inui, Nobuaki Egashira, Kenichi Mishima, Akiko Yano, Yoshiaki Matsumoto, Nobuyoshi Hasebe, Kohji Abe, Kazuhide Hayakawa, Tomoaki Ikeda, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We studied the effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT), a 5-HT1A receptor agonist, on both Δ9-tetrahydrocannabinol-induced spatial memory impairment in an 8-arm radial maze, and the reduction of acetylcholine release in the dorsal hippocampus as assessed by in vivo microdialysis in rats. A 6 mg/kg i.p. dose of Δ9-tetrahydrocannabinol impaired spatial memory in the 8-arm radial maze and decreased the acetyl-choline release in the dorsal hippocampus. 8-OHD-PAT, at very low doses of 0.1-0.3 μg/kg, reversed both the impairment of spatial memory and the decrease in acetylcholine release induced by Δ9-tetrahydrocannabinol. These findings suggest that low doses of 8-OHDPAT may improve Δ9 -tetrahy-drocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalNeurotoxicity Research
Volume6
Issue number2
DOIs
Publication statusPublished - Dec 1 2004
Externally publishedYes

Keywords

  • 5-HT receptor
  • 8-OHDPAT
  • Acetylcholine
  • Hippocampus
  • Serotonin
  • Spatial memory
  • Δ-tetrahydrocannabinol

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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