The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

James W. Fawcett, Toshitaka Oohashi, Tommaso Pizzorusso

Research output: Contribution to journalReview article

14 Citations (Scopus)


Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure — the perinodal ECM — surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.

Original languageEnglish
JournalNature Reviews Neuroscience
Publication statusPublished - Jan 1 2019


ASJC Scopus subject areas

  • Neuroscience(all)

Cite this