Abstract
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure — the perinodal ECM — surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.
| Original language | English |
|---|---|
| Journal | Nature Reviews Neuroscience |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function. / Fawcett, James W.; Oohashi, Toshitaka; Pizzorusso, Tommaso.
In: Nature Reviews Neuroscience, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
AU - Fawcett, James W.
AU - Oohashi, Toshitaka
AU - Pizzorusso, Tommaso
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure — the perinodal ECM — surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.
AB - Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure — the perinodal ECM — surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.
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U2 - 10.1038/s41583-019-0196-3
DO - 10.1038/s41583-019-0196-3
M3 - Review article
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
SN - 1471-003X
ER -