Abstract
Synaptic vesicles have important roles in the neural transmission at nerve terminals: the storage and the controlled exocytosis of neurotransmitters. At least two different factors are responsible for the concentration process: the vacuolar-type H(+)-ATPase (V-ATPase), establishing an electrochemical gradient of protons, and specific transport systems for transmitters. We will discuss our recent progress on the energy-transducing systems in synaptic vesicles: (1) structural aspects of V-ATPase; (2) energy coupling of transport of transmitters; (3) reconstitution of transporters; (4) effects of neurotoxins and neuron blocking agents; (5) function of synaptic-vesicle-like microvesicles from endocrine tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 171-178 |
| Number of pages | 8 |
| Journal | The Journal of experimental biology |
| Volume | 172 |
| Publication status | Published - Nov 1992 |
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Physiology
- Aquatic Science
- Animal Science and Zoology
- Molecular Biology
- Insect Science
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Moriyama, Y., Maeda, M., & Futai, M. (1992). The role of V-ATPase in neuronal and endocrine systems. The Journal of experimental biology, 172, 171-178.