The role of V-ATPase in neuronal and endocrine systems.

Y. Moriyama, M. Maeda, M. Futai

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Synaptic vesicles have important roles in the neural transmission at nerve terminals: the storage and the controlled exocytosis of neurotransmitters. At least two different factors are responsible for the concentration process: the vacuolar-type H(+)-ATPase (V-ATPase), establishing an electrochemical gradient of protons, and specific transport systems for transmitters. We will discuss our recent progress on the energy-transducing systems in synaptic vesicles: (1) structural aspects of V-ATPase; (2) energy coupling of transport of transmitters; (3) reconstitution of transporters; (4) effects of neurotoxins and neuron blocking agents; (5) function of synaptic-vesicle-like microvesicles from endocrine tissues.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalJournal of Experimental Biology
Volume172
Publication statusPublished - Nov 1992
Externally publishedYes

Fingerprint

endocrine system
H-transporting ATP synthase
Endocrine System
Synaptic Vesicles
vesicle
Adenosine Triphosphatases
Vacuolar Proton-Translocating ATPases
synaptic transmission
neurotoxins
exocytosis
energy
Exocytosis
Neurotoxins
neurotransmitters
Synaptic Transmission
protons
Neurotransmitter Agents
transporters
Protons
nerve tissue

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Moriyama, Y., Maeda, M., & Futai, M. (1992). The role of V-ATPase in neuronal and endocrine systems. Journal of Experimental Biology, 172, 171-178.

The role of V-ATPase in neuronal and endocrine systems. / Moriyama, Y.; Maeda, M.; Futai, M.

In: Journal of Experimental Biology, Vol. 172, 11.1992, p. 171-178.

Research output: Contribution to journalArticle

Moriyama, Y, Maeda, M & Futai, M 1992, 'The role of V-ATPase in neuronal and endocrine systems.', Journal of Experimental Biology, vol. 172, pp. 171-178.
Moriyama, Y. ; Maeda, M. ; Futai, M. / The role of V-ATPase in neuronal and endocrine systems. In: Journal of Experimental Biology. 1992 ; Vol. 172. pp. 171-178.
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