The role of V-ATPase in neuronal and endocrine systems.

Y. Moriyama, M. Maeda, M. Futai

Research output: Contribution to journalReview articlepeer-review

60 Citations (Scopus)


Synaptic vesicles have important roles in the neural transmission at nerve terminals: the storage and the controlled exocytosis of neurotransmitters. At least two different factors are responsible for the concentration process: the vacuolar-type H(+)-ATPase (V-ATPase), establishing an electrochemical gradient of protons, and specific transport systems for transmitters. We will discuss our recent progress on the energy-transducing systems in synaptic vesicles: (1) structural aspects of V-ATPase; (2) energy coupling of transport of transmitters; (3) reconstitution of transporters; (4) effects of neurotoxins and neuron blocking agents; (5) function of synaptic-vesicle-like microvesicles from endocrine tissues.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalThe Journal of experimental biology
Publication statusPublished - Nov 1992

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science


Dive into the research topics of 'The role of V-ATPase in neuronal and endocrine systems.'. Together they form a unique fingerprint.

Cite this