Abstract
Synaptic vesicles have important roles in the neural transmission at nerve terminals: the storage and the controlled exocytosis of neurotransmitters. At least two different factors are responsible for the concentration process: the vacuolar-type H(+)-ATPase (V-ATPase), establishing an electrochemical gradient of protons, and specific transport systems for transmitters. We will discuss our recent progress on the energy-transducing systems in synaptic vesicles: (1) structural aspects of V-ATPase; (2) energy coupling of transport of transmitters; (3) reconstitution of transporters; (4) effects of neurotoxins and neuron blocking agents; (5) function of synaptic-vesicle-like microvesicles from endocrine tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 171-178 |
| Number of pages | 8 |
| Journal | Journal of Experimental Biology |
| Volume | 172 |
| Publication status | Published - Nov 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)
Cite this
The role of V-ATPase in neuronal and endocrine systems. / Moriyama, Y.; Maeda, M.; Futai, M.
In: Journal of Experimental Biology, Vol. 172, 11.1992, p. 171-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of V-ATPase in neuronal and endocrine systems.
AU - Moriyama, Y.
AU - Maeda, M.
AU - Futai, M.
PY - 1992/11
Y1 - 1992/11
N2 - Synaptic vesicles have important roles in the neural transmission at nerve terminals: the storage and the controlled exocytosis of neurotransmitters. At least two different factors are responsible for the concentration process: the vacuolar-type H(+)-ATPase (V-ATPase), establishing an electrochemical gradient of protons, and specific transport systems for transmitters. We will discuss our recent progress on the energy-transducing systems in synaptic vesicles: (1) structural aspects of V-ATPase; (2) energy coupling of transport of transmitters; (3) reconstitution of transporters; (4) effects of neurotoxins and neuron blocking agents; (5) function of synaptic-vesicle-like microvesicles from endocrine tissues.
AB - Synaptic vesicles have important roles in the neural transmission at nerve terminals: the storage and the controlled exocytosis of neurotransmitters. At least two different factors are responsible for the concentration process: the vacuolar-type H(+)-ATPase (V-ATPase), establishing an electrochemical gradient of protons, and specific transport systems for transmitters. We will discuss our recent progress on the energy-transducing systems in synaptic vesicles: (1) structural aspects of V-ATPase; (2) energy coupling of transport of transmitters; (3) reconstitution of transporters; (4) effects of neurotoxins and neuron blocking agents; (5) function of synaptic-vesicle-like microvesicles from endocrine tissues.
UR - http://www.scopus.com/inward/record.url?scp=0026950284&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026950284&partnerID=8YFLogxK
M3 - Article
VL - 172
SP - 171
EP - 178
JO - Journal of Experimental Biology
JF - Journal of Experimental Biology
SN - 0022-0949
ER -