The role of the capsule of the Streptococcus milleri group in its pathogenicity

Shuzo Kanamori, Nobuchika Kusano, Takashi Shinzato, Atsushi Saito

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Study of the pathogenicity of encapsulated strains of the Streptococcus milleri group (SMG) was performed by examination of the ability to cause subcutaneous abscesses in mice and by phagocytosis and phagocytic killing of human polymorphonuclear neutrophils (PMNs) against the organisms. All 3 encapsulated isolates from patients with pneumonia or lung abscess induced abscesses in the mice; however, only 2 of 20 unencapsulated isolates from patients with lung abscess or thoracic empyema did so. The 3 encapsulated strains inhibited more phagocytosis and phagocytic killing of PMNs than the unencapsulated strains. In addition, encapsular material separated from Streptococcus constellatus RZYK001 also inhibited phagocytosis and phagocytic killing in proportion to increasing concentrations of the capsular material. These results suggest that capsular material produced by SMG might be a pathogenic factor.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalJournal of Infection and Chemotherapy
Volume10
Issue number2
DOIs
Publication statusPublished - Apr 2004

Fingerprint

Streptococcus milleri Group
Phagocytosis
Capsules
Virulence
Lung Abscess
Abscess
Streptococcus constellatus
Neutrophils
Pleural Empyema
Pneumonia

Keywords

  • Abscess
  • Capsule
  • Pathogenicity
  • Phagocytosis
  • Streptococcus milleri group

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

The role of the capsule of the Streptococcus milleri group in its pathogenicity. / Kanamori, Shuzo; Kusano, Nobuchika; Shinzato, Takashi; Saito, Atsushi.

In: Journal of Infection and Chemotherapy, Vol. 10, No. 2, 04.2004, p. 105-109.

Research output: Contribution to journalArticle

Kanamori, Shuzo ; Kusano, Nobuchika ; Shinzato, Takashi ; Saito, Atsushi. / The role of the capsule of the Streptococcus milleri group in its pathogenicity. In: Journal of Infection and Chemotherapy. 2004 ; Vol. 10, No. 2. pp. 105-109.
@article{f2ee87da24ef4bb4b3af15ea4a064940,
title = "The role of the capsule of the Streptococcus milleri group in its pathogenicity",
abstract = "Study of the pathogenicity of encapsulated strains of the Streptococcus milleri group (SMG) was performed by examination of the ability to cause subcutaneous abscesses in mice and by phagocytosis and phagocytic killing of human polymorphonuclear neutrophils (PMNs) against the organisms. All 3 encapsulated isolates from patients with pneumonia or lung abscess induced abscesses in the mice; however, only 2 of 20 unencapsulated isolates from patients with lung abscess or thoracic empyema did so. The 3 encapsulated strains inhibited more phagocytosis and phagocytic killing of PMNs than the unencapsulated strains. In addition, encapsular material separated from Streptococcus constellatus RZYK001 also inhibited phagocytosis and phagocytic killing in proportion to increasing concentrations of the capsular material. These results suggest that capsular material produced by SMG might be a pathogenic factor.",
keywords = "Abscess, Capsule, Pathogenicity, Phagocytosis, Streptococcus milleri group",
author = "Shuzo Kanamori and Nobuchika Kusano and Takashi Shinzato and Atsushi Saito",
year = "2004",
month = "4",
doi = "10.1007/s10156-004-0305-7",
language = "English",
volume = "10",
pages = "105--109",
journal = "Journal of Infection and Chemotherapy",
issn = "1341-321X",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - The role of the capsule of the Streptococcus milleri group in its pathogenicity

AU - Kanamori, Shuzo

AU - Kusano, Nobuchika

AU - Shinzato, Takashi

AU - Saito, Atsushi

PY - 2004/4

Y1 - 2004/4

N2 - Study of the pathogenicity of encapsulated strains of the Streptococcus milleri group (SMG) was performed by examination of the ability to cause subcutaneous abscesses in mice and by phagocytosis and phagocytic killing of human polymorphonuclear neutrophils (PMNs) against the organisms. All 3 encapsulated isolates from patients with pneumonia or lung abscess induced abscesses in the mice; however, only 2 of 20 unencapsulated isolates from patients with lung abscess or thoracic empyema did so. The 3 encapsulated strains inhibited more phagocytosis and phagocytic killing of PMNs than the unencapsulated strains. In addition, encapsular material separated from Streptococcus constellatus RZYK001 also inhibited phagocytosis and phagocytic killing in proportion to increasing concentrations of the capsular material. These results suggest that capsular material produced by SMG might be a pathogenic factor.

AB - Study of the pathogenicity of encapsulated strains of the Streptococcus milleri group (SMG) was performed by examination of the ability to cause subcutaneous abscesses in mice and by phagocytosis and phagocytic killing of human polymorphonuclear neutrophils (PMNs) against the organisms. All 3 encapsulated isolates from patients with pneumonia or lung abscess induced abscesses in the mice; however, only 2 of 20 unencapsulated isolates from patients with lung abscess or thoracic empyema did so. The 3 encapsulated strains inhibited more phagocytosis and phagocytic killing of PMNs than the unencapsulated strains. In addition, encapsular material separated from Streptococcus constellatus RZYK001 also inhibited phagocytosis and phagocytic killing in proportion to increasing concentrations of the capsular material. These results suggest that capsular material produced by SMG might be a pathogenic factor.

KW - Abscess

KW - Capsule

KW - Pathogenicity

KW - Phagocytosis

KW - Streptococcus milleri group

UR - http://www.scopus.com/inward/record.url?scp=2342588187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342588187&partnerID=8YFLogxK

U2 - 10.1007/s10156-004-0305-7

DO - 10.1007/s10156-004-0305-7

M3 - Article

VL - 10

SP - 105

EP - 109

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

SN - 1341-321X

IS - 2

ER -