The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer

Fahad Quhal, Pawel Rajwa, Keiichiro Mori, Ekaterina Laukhtina, Nico C. Grossmann, Victor M. Schuettfort, Frederik König, Abdulmajeed Aydh, Reza S. Motlagh, Satoshi Katayama, Hadi Mostafai, Benjamin Pradere, Giancarlo Marra, Paolo Gontero, Romain Mathieu, Pierre I. Karakiewicz, Alberto Briganti, Shahrokh F. Shariat, Axel Heidenreich

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP). Material and Methods: We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000–2016. None of the patients had clinical lymph node involvement before SRP. The effect of the number of removed lymph nodes (RLNs) and the number of positive lymph nodes (PLNs) on biochemical recurrence (BCR)-free survival, metastases free survival, and overall survival (OS) was tested in multivariable Cox regression analyses. Results: About 334 patients underwent SRP and pelvic lymph node dissection (PLND). Lymph node involvement was associated with increased risk of BCR (p <.001), metastasis (p <.001), and overall mortality (p =.006). In a multivariable Cox regression analysis, an increased number of RLNs significantly lowered the risk of BCR (hazard ratio [HR] 0.96, p =.01). In patients with positive lymph nodes, a higher number of RLNs and a lower number of PLNs were associated with improved freedom from BCR (HR 0.89, p =.001 and HR 1.34, p =.008, respectively). At a median follow-up of 23.9 months (interquartile range, 4.7–37.7), neither the number of RLNs nor the number of PLNs were associated with OS (p =.69 and p =.34, respectively). Conclusion: Pathologic lymph node involvement increased the risk of BCR, metastasis and overall mortality in radiation-recurrent PCa patients undergoing SRP. The risk of BCR decreased steadily with a higher number of RLNs during SRP. Further research is needed to support this conclusion and develop a precise therapeutic adjuvant strategy based on the number of RLNs and PLNs.

Original languageEnglish
Pages (from-to)765-771
Number of pages7
Issue number11
Publication statusPublished - Aug 1 2021


  • BCR
  • localized
  • lymphadenectomy
  • metastasis

ASJC Scopus subject areas

  • Oncology
  • Urology


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