The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer

Keiichiro Nakamura, Fernando Abarzua, Atsushi Hongo, Junichi Kodama, Yasutomo Nasu, Hiromi Kumon, Yuji Hiramatsu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is a Kunitz-type serine protease inhibitor that has a broad inhibitory spectrum against serine proteases. This is the first study to investigate the role of HAI-1 and its clinical importance in cervical cancer. We attempted to investigate the inhibitory effects of HAI-1 using cervical carcinoma cell lines SiHa with integrated human papillomavirus (HPV) 16 and HeLa with integrated HPV 18. HAI-1 expression in cervical cancer (n=91) were assessed by immunohistochemistry. HAI-1 was found to be a potential inhibitory effects mediated by reduction of hepsin, matriptase and prostasin expression. This led to apoptosis through a reduction in the levels of Bcl-2, Bcl-xL, MUPP-1 and MAGI-3 in cervical cancer cell lines. There were significant correlations between HAI-1 expression and stage (p=0.013), tumor size (p=0.002), stromal invasion (p

Original languageEnglish
Pages (from-to)239-248
Number of pages10
JournalInternational Journal of Oncology
Volume35
Issue number2
DOIs
Publication statusPublished - 2009

Fingerprint

Uterine Cervical Neoplasms
Cell Line
Human papillomavirus 18
Serine Proteinase Inhibitors
Human papillomavirus 16
Serine Proteases
HGF activator
Immunohistochemistry
Apoptosis
Carcinoma
Neoplasms

Keywords

  • Apoptotic pathway
  • Cervical cancer
  • Favorable prognostic marker
  • Hepatocyte growth factor activator inhibitor-1
  • Therapeutic target

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer. / Nakamura, Keiichiro; Abarzua, Fernando; Hongo, Atsushi; Kodama, Junichi; Nasu, Yasutomo; Kumon, Hiromi; Hiramatsu, Yuji.

In: International Journal of Oncology, Vol. 35, No. 2, 2009, p. 239-248.

Research output: Contribution to journalArticle

Nakamura, Keiichiro ; Abarzua, Fernando ; Hongo, Atsushi ; Kodama, Junichi ; Nasu, Yasutomo ; Kumon, Hiromi ; Hiramatsu, Yuji. / The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer. In: International Journal of Oncology. 2009 ; Vol. 35, No. 2. pp. 239-248.
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