The role of chemoattractant receptors in shaping the tumor microenvironment

Jiamin Zhou, Yi Xiang, Teizo Yoshimura, Keqiang Chen, Wanghua Gong, Jian Huang, Ye Zhou, Xiaohong Yao, Xiuwu Bian, Ji Ming Wang

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Chemoattractant receptors are a family of seven transmembrane G protein coupled receptors (GPCRs) initially found to mediate the chemotaxis and activation of immune cells. During the past decades, the functions of these GPCRs have been discovered to not only regulate leukocyte trafficking and promote immune responses, but also play important roles in homeostasis, development, angiogenesis, and tumor progression. Accumulating evidence indicates that chemoattractant GPCRs and their ligands promote the progression of malignant tumors based on their capacity to orchestrate the infiltration of the tumor microenvironment by immune cells, endothelial cells, fibroblasts, and mesenchymal cells. This facilitates the interaction of tumor cells with host cells, tumor cells with tumor cells, and host cells with host cells to provide a basis for the expansion of established tumors and development of distant metastasis. In addition, many malignant tumors of the nonhematopoietic origin express multiple chemoattractant GPCRs that increase the invasiveness and metastasis of tumor cells. Therefore, GPCRs and their ligands constitute targets for the development of novel antitumor therapeutics.

Original languageEnglish
Article number751392
JournalBioMed research international
Volume2014
DOIs
Publication statusPublished - 2014
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Zhou, J., Xiang, Y., Yoshimura, T., Chen, K., Gong, W., Huang, J., Zhou, Y., Yao, X., Bian, X., & Wang, J. M. (2014). The role of chemoattractant receptors in shaping the tumor microenvironment. BioMed research international, 2014, [751392]. https://doi.org/10.1155/2014/751392