The role of caveolin-1 in prostate cancer: Clinical implications

T. C. Thompson, S. A. Tahir, L. Li, M. Watanabe, K. Naruishi, G. Yang, D. Kadmon, C. J. Logothetis, P. Troncoso, C. Ren, A. Goltsov, S. Park

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.

Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Angiogenesis
  • Biomarkers
  • Caveolin-1
  • Progression

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

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  • Cite this

    Thompson, T. C., Tahir, S. A., Li, L., Watanabe, M., Naruishi, K., Yang, G., Kadmon, D., Logothetis, C. J., Troncoso, P., Ren, C., Goltsov, A., & Park, S. (2010). The role of caveolin-1 in prostate cancer: Clinical implications. Prostate Cancer and Prostatic Diseases, 13(1), 6-11. https://doi.org/10.1038/pcan.2009.29