The relationship between paroxysmal kinesigenic choreoathetosis and epilepsy

Iori Ohmori, Y. Ohtsuka, T. Ogino, H. Yoshinaga, Katsuhiro Kobayashi, E. Oka

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: To clarify the relationship between paroxysmal kinesigenic choreoathetosis (PKC) and epilepsy, we investigated the clinical and electroencephalographic (EEG) findings of patients with familial PKC and epilepsy, as well as sporadic cases with both PKC and epilepsy. Patients and Methods: Patients consisted of 12 familial cases from seven families and three sporadic cases. The period of follow-up ranged from 17 months to 33 years, 7 months (average: 16 years, 8 months). During the follow-up, a total of 163 EEGs (11 EEGs per subject) were studied, including interictal and ictal EEGs. Results: Transient epileptic discharges were found in ten of the 15 patients (66.7%) during the clinical course. As for focus, centro-midtemporal and frontal spikes were most often observed. The ictal EEG of an afebrile convulsion in one patient showed a partial seizure with secondary generalization which originated from the frontal area. Conclusions: It appears that patients who suffer from both PKC and epilepsy have a functional abnormality of the cerebral cortex, particularly in the perirolandic and frontal regions.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalNeuropediatrics
Volume33
Issue number1
DOIs
Publication statusPublished - 2002

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Epilepsy
Electroencephalography
Seizures
Stroke
Cerebral Cortex
Familial paroxysmal dystonia

Keywords

  • Cortical Hyperexcitability
  • Cortico-Striato-Pallido-Thalamic Loop
  • Epilepsy
  • Paroxysmal Kinesigenic Choreoathetosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

The relationship between paroxysmal kinesigenic choreoathetosis and epilepsy. / Ohmori, Iori; Ohtsuka, Y.; Ogino, T.; Yoshinaga, H.; Kobayashi, Katsuhiro; Oka, E.

In: Neuropediatrics, Vol. 33, No. 1, 2002, p. 15-20.

Research output: Contribution to journalArticle

Ohmori, Iori ; Ohtsuka, Y. ; Ogino, T. ; Yoshinaga, H. ; Kobayashi, Katsuhiro ; Oka, E. / The relationship between paroxysmal kinesigenic choreoathetosis and epilepsy. In: Neuropediatrics. 2002 ; Vol. 33, No. 1. pp. 15-20.
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