Abstract
Purpose: To clarify the relationship between paroxysmal kinesigenic choreoathetosis (PKC) and epilepsy, we investigated the clinical and electroencephalographic (EEG) findings of patients with familial PKC and epilepsy, as well as sporadic cases with both PKC and epilepsy. Patients and Methods: Patients consisted of 12 familial cases from seven families and three sporadic cases. The period of follow-up ranged from 17 months to 33 years, 7 months (average: 16 years, 8 months). During the follow-up, a total of 163 EEGs (11 EEGs per subject) were studied, including interictal and ictal EEGs. Results: Transient epileptic discharges were found in ten of the 15 patients (66.7%) during the clinical course. As for focus, centro-midtemporal and frontal spikes were most often observed. The ictal EEG of an afebrile convulsion in one patient showed a partial seizure with secondary generalization which originated from the frontal area. Conclusions: It appears that patients who suffer from both PKC and epilepsy have a functional abnormality of the cerebral cortex, particularly in the perirolandic and frontal regions.
| Original language | English |
|---|---|
| Pages (from-to) | 15-20 |
| Number of pages | 6 |
| Journal | Neuropediatrics |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Cortical Hyperexcitability
- Cortico-Striato-Pallido-Thalamic Loop
- Epilepsy
- Paroxysmal Kinesigenic Choreoathetosis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology
Cite this
The relationship between paroxysmal kinesigenic choreoathetosis and epilepsy. / Ohmori, Iori; Ohtsuka, Y.; Ogino, T.; Yoshinaga, H.; Kobayashi, Katsuhiro; Oka, E.
In: Neuropediatrics, Vol. 33, No. 1, 2002, p. 15-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The relationship between paroxysmal kinesigenic choreoathetosis and epilepsy
AU - Ohmori, Iori
AU - Ohtsuka, Y.
AU - Ogino, T.
AU - Yoshinaga, H.
AU - Kobayashi, Katsuhiro
AU - Oka, E.
PY - 2002
Y1 - 2002
N2 - Purpose: To clarify the relationship between paroxysmal kinesigenic choreoathetosis (PKC) and epilepsy, we investigated the clinical and electroencephalographic (EEG) findings of patients with familial PKC and epilepsy, as well as sporadic cases with both PKC and epilepsy. Patients and Methods: Patients consisted of 12 familial cases from seven families and three sporadic cases. The period of follow-up ranged from 17 months to 33 years, 7 months (average: 16 years, 8 months). During the follow-up, a total of 163 EEGs (11 EEGs per subject) were studied, including interictal and ictal EEGs. Results: Transient epileptic discharges were found in ten of the 15 patients (66.7%) during the clinical course. As for focus, centro-midtemporal and frontal spikes were most often observed. The ictal EEG of an afebrile convulsion in one patient showed a partial seizure with secondary generalization which originated from the frontal area. Conclusions: It appears that patients who suffer from both PKC and epilepsy have a functional abnormality of the cerebral cortex, particularly in the perirolandic and frontal regions.
AB - Purpose: To clarify the relationship between paroxysmal kinesigenic choreoathetosis (PKC) and epilepsy, we investigated the clinical and electroencephalographic (EEG) findings of patients with familial PKC and epilepsy, as well as sporadic cases with both PKC and epilepsy. Patients and Methods: Patients consisted of 12 familial cases from seven families and three sporadic cases. The period of follow-up ranged from 17 months to 33 years, 7 months (average: 16 years, 8 months). During the follow-up, a total of 163 EEGs (11 EEGs per subject) were studied, including interictal and ictal EEGs. Results: Transient epileptic discharges were found in ten of the 15 patients (66.7%) during the clinical course. As for focus, centro-midtemporal and frontal spikes were most often observed. The ictal EEG of an afebrile convulsion in one patient showed a partial seizure with secondary generalization which originated from the frontal area. Conclusions: It appears that patients who suffer from both PKC and epilepsy have a functional abnormality of the cerebral cortex, particularly in the perirolandic and frontal regions.
KW - Cortical Hyperexcitability
KW - Cortico-Striato-Pallido-Thalamic Loop
KW - Epilepsy
KW - Paroxysmal Kinesigenic Choreoathetosis
UR - http://www.scopus.com/inward/record.url?scp=0036205192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036205192&partnerID=8YFLogxK
U2 - 10.1055/s-2002-23594
DO - 10.1055/s-2002-23594
M3 - Article
C2 - 11930271
AN - SCOPUS:0036205192
VL - 33
SP - 15
EP - 20
JO - Neuropediatrics
JF - Neuropediatrics
SN - 0174-304X
IS - 1
ER -