The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer

Juichiro Konishi, Shinichi Toyooka, Motoi Aoe, Yasushi Omura, Kazuhiro Washio, Kazunori Tsukuda, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Tumor-associated antigens recognized by cellular or humoral effectors of the immune system are potential targets for antigen-specific cancer immunotherapy. NY-ESO-1 is one of the most immunogenic cancer/testis (CT) antigens and emerges as the potential candidate for specific immunotherapy. We studied mRNA expression status of NY-ESO-1 in 63 cases of NSCLCs using the real-time reverse transcription PCR to examine the relationship between its expression and clinicopathological features. NY-ESO-1 expression was present in 20 (32%) of 63 NSCLC cases and significantly increased with the advancement of disease stage in TNM classification (P=0.013), especially related to lymph node metastasis (P=0.020). Moreover, frequency of NY-ESO-1 expression was related to the degree of pathological differentiation (P=0.035). The quantity of NY-ESO-1 expression by real-time RT-PCR was not correlated with any clinicopathological factor. Our results demonstrate that the NY-ESO-1 expression was frequently present in primary NSCLC, especially advanced cases with lymph node metastasis. In addition, the high incidence of NY-ESO-1 expression in NSCLC suggests the possibility of a specific immunotherapy for NSCLC.

Original languageEnglish
Pages (from-to)1063-1067
Number of pages5
JournalOncology reports
Volume11
Issue number5
Publication statusPublished - May 2004

Keywords

  • Cancer/testis antigen
  • NY-ESO-1
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., & Shimizu, N. (2004). The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer. Oncology reports, 11(5), 1063-1067.