The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease

Chikako Ikeda, Osamu Yokota, Shigeto Nagao, Hideki Ishizu, Etsuko Oshima, Masato Hasegawa, Yuko Okahisa, Seishi Terada, Norihito Yamada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Progressive supranuclear palsy (PSP) cases frequently have argyrophilic grain disease (AGD). However, the PSP-like tau pathology in AGD cases has not been fully clarified. To address this, we examined tau pathologies in the subcortical nuclei and frontal cortex in 19 AGD cases that did not meet the pathological criteria of PSP or corticobasal degeneration, nine PSP cases and 20 Braak NFT stage-matched controls. Of the 19 AGD cases, five (26.3%) had a few Gallyas-positive tau-positive tufted astrocytes (TAs) and Gallyas-negative tau-positive TA-like astrocytic inclusions (TAIs), and six (31.6%) had only TAIs in the striatum and/or frontal cortex. Subcortical tau pathology was sequentially and significantly greater in AGD cases lacking these tau-positive astrocytic lesions, AGD cases having them, and PSP cases than in controls. There was a significant correlation between three histologic factors, including the AGD stage and the quantities of subcortical neuronal and astrocytic tau pathologies. Tau immunoblotting demonstrated 68- and 64-kDa bands and 33-kDa low-molecular mass tau fragments in PSP cases, and although with lesser intensity, in AGD cases with and without TAs and TAIs also. Given these findings, the progression of AGD may be associated with development of the neuronal and astrocytic tau pathologies characteristic of PSP.

Original languageEnglish
Pages (from-to)488-505
Number of pages18
JournalBrain Pathology
Volume26
Issue number4
DOIs
Publication statusPublished - Jul 1 2016

Fingerprint

Progressive Supranuclear Palsy
Pathology
Astrocytes
Frontal Lobe
Immunoblotting

Keywords

  • argyrophilic grain disease
  • progressive supranuclear palsy
  • subcortical nuclei
  • tau
  • tufted astrocyte

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease. / Ikeda, Chikako; Yokota, Osamu; Nagao, Shigeto; Ishizu, Hideki; Oshima, Etsuko; Hasegawa, Masato; Okahisa, Yuko; Terada, Seishi; Yamada, Norihito.

In: Brain Pathology, Vol. 26, No. 4, 01.07.2016, p. 488-505.

Research output: Contribution to journalArticle

Ikeda, Chikako ; Yokota, Osamu ; Nagao, Shigeto ; Ishizu, Hideki ; Oshima, Etsuko ; Hasegawa, Masato ; Okahisa, Yuko ; Terada, Seishi ; Yamada, Norihito. / The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease. In: Brain Pathology. 2016 ; Vol. 26, No. 4. pp. 488-505.
@article{f57065a2a86a4253b6a108e2abb28ee3,
title = "The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease",
abstract = "Progressive supranuclear palsy (PSP) cases frequently have argyrophilic grain disease (AGD). However, the PSP-like tau pathology in AGD cases has not been fully clarified. To address this, we examined tau pathologies in the subcortical nuclei and frontal cortex in 19 AGD cases that did not meet the pathological criteria of PSP or corticobasal degeneration, nine PSP cases and 20 Braak NFT stage-matched controls. Of the 19 AGD cases, five (26.3{\%}) had a few Gallyas-positive tau-positive tufted astrocytes (TAs) and Gallyas-negative tau-positive TA-like astrocytic inclusions (TAIs), and six (31.6{\%}) had only TAIs in the striatum and/or frontal cortex. Subcortical tau pathology was sequentially and significantly greater in AGD cases lacking these tau-positive astrocytic lesions, AGD cases having them, and PSP cases than in controls. There was a significant correlation between three histologic factors, including the AGD stage and the quantities of subcortical neuronal and astrocytic tau pathologies. Tau immunoblotting demonstrated 68- and 64-kDa bands and 33-kDa low-molecular mass tau fragments in PSP cases, and although with lesser intensity, in AGD cases with and without TAs and TAIs also. Given these findings, the progression of AGD may be associated with development of the neuronal and astrocytic tau pathologies characteristic of PSP.",
keywords = "argyrophilic grain disease, progressive supranuclear palsy, subcortical nuclei, tau, tufted astrocyte",
author = "Chikako Ikeda and Osamu Yokota and Shigeto Nagao and Hideki Ishizu and Etsuko Oshima and Masato Hasegawa and Yuko Okahisa and Seishi Terada and Norihito Yamada",
year = "2016",
month = "7",
day = "1",
doi = "10.1111/bpa.12319",
language = "English",
volume = "26",
pages = "488--505",
journal = "Brain Pathology",
issn = "1015-6305",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease

AU - Ikeda, Chikako

AU - Yokota, Osamu

AU - Nagao, Shigeto

AU - Ishizu, Hideki

AU - Oshima, Etsuko

AU - Hasegawa, Masato

AU - Okahisa, Yuko

AU - Terada, Seishi

AU - Yamada, Norihito

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Progressive supranuclear palsy (PSP) cases frequently have argyrophilic grain disease (AGD). However, the PSP-like tau pathology in AGD cases has not been fully clarified. To address this, we examined tau pathologies in the subcortical nuclei and frontal cortex in 19 AGD cases that did not meet the pathological criteria of PSP or corticobasal degeneration, nine PSP cases and 20 Braak NFT stage-matched controls. Of the 19 AGD cases, five (26.3%) had a few Gallyas-positive tau-positive tufted astrocytes (TAs) and Gallyas-negative tau-positive TA-like astrocytic inclusions (TAIs), and six (31.6%) had only TAIs in the striatum and/or frontal cortex. Subcortical tau pathology was sequentially and significantly greater in AGD cases lacking these tau-positive astrocytic lesions, AGD cases having them, and PSP cases than in controls. There was a significant correlation between three histologic factors, including the AGD stage and the quantities of subcortical neuronal and astrocytic tau pathologies. Tau immunoblotting demonstrated 68- and 64-kDa bands and 33-kDa low-molecular mass tau fragments in PSP cases, and although with lesser intensity, in AGD cases with and without TAs and TAIs also. Given these findings, the progression of AGD may be associated with development of the neuronal and astrocytic tau pathologies characteristic of PSP.

AB - Progressive supranuclear palsy (PSP) cases frequently have argyrophilic grain disease (AGD). However, the PSP-like tau pathology in AGD cases has not been fully clarified. To address this, we examined tau pathologies in the subcortical nuclei and frontal cortex in 19 AGD cases that did not meet the pathological criteria of PSP or corticobasal degeneration, nine PSP cases and 20 Braak NFT stage-matched controls. Of the 19 AGD cases, five (26.3%) had a few Gallyas-positive tau-positive tufted astrocytes (TAs) and Gallyas-negative tau-positive TA-like astrocytic inclusions (TAIs), and six (31.6%) had only TAIs in the striatum and/or frontal cortex. Subcortical tau pathology was sequentially and significantly greater in AGD cases lacking these tau-positive astrocytic lesions, AGD cases having them, and PSP cases than in controls. There was a significant correlation between three histologic factors, including the AGD stage and the quantities of subcortical neuronal and astrocytic tau pathologies. Tau immunoblotting demonstrated 68- and 64-kDa bands and 33-kDa low-molecular mass tau fragments in PSP cases, and although with lesser intensity, in AGD cases with and without TAs and TAIs also. Given these findings, the progression of AGD may be associated with development of the neuronal and astrocytic tau pathologies characteristic of PSP.

KW - argyrophilic grain disease

KW - progressive supranuclear palsy

KW - subcortical nuclei

KW - tau

KW - tufted astrocyte

UR - http://www.scopus.com/inward/record.url?scp=84978485294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978485294&partnerID=8YFLogxK

U2 - 10.1111/bpa.12319

DO - 10.1111/bpa.12319

M3 - Article

C2 - 26439704

AN - SCOPUS:84978485294

VL - 26

SP - 488

EP - 505

JO - Brain Pathology

JF - Brain Pathology

SN - 1015-6305

IS - 4

ER -