The relationship between aberrant methylation and survival in non-small-cell lung cancers

S. Toyooka, M. Suzuki, R. Maruyama, K. O. Toyooka, K. Tsukuda, Y. Fukuyama, T. Iizasa, M. Aoe, H. Date, T. Fujisawa, N. Shimizu, A. F. Gazdar

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

The present study examined the relationship between methylation of five genes (p16INK4a, RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16INK4a methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.

Original languageEnglish
Pages (from-to)771-774
Number of pages4
JournalBritish Journal of Cancer
Volume91
Issue number4
DOIs
Publication statusPublished - Aug 16 2004

Keywords

  • Adenocarcinoma of lung
  • Methylation
  • Non-small-cell lung cancer
  • p16

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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