The regulation of ICAM-1 and LFA-1 interaction by autocoids and statins: A novel strategy for controlling inflammation and immune responses

Masahiro Nishibori, Hideo K. Takahashi, Shuji Mori

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Histamine, prostaglandin E2, and catecholamines have been demonstrated to regulate the innate and acquired immune responses. In this review, we describe one of the mechanisms common to the action of these agonists; the regulation of the expression of costimulatory adhesion molecules such as ICAM-1 and B7 antigens on monocytes/macrophages. The specific receptor subtypes involved in the action of each agonist were H2 for histamine, EP2/EP4 for prostaglandin E2, and β2 for catecholamines, all of which are coupled with adenylate cyclase via Gs protein. The regulation of the expression of adhesion molecules by these agonists in turn leads to the modulation of subsequent cytokine production mediated by cell-cell interaction under different stimuli. Histamine is synthesized in monocytes and T cells by the induction of histidine decarboxylase. The inducible histamine has different dynamics from that in-storage granules of mast cells and basophils. Also, noradrenaline appears to be synthesized in lymphocytes. Thus, immune cells can produce histamine, prostaglandins, and noradrenaline by themselves and modulate the cell-cell interaction between monocytes and other cells. Some of the inhibitors of HMG-CoA reductase were shown to bind to the ICAM-1-binding domain of LFA-1, reducing the interaction mediated by ICAM-1/LFA-1. The regulation of interaction mediated by adhesion molecules may provide a new target for controlling inflammatory and immune responses.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalJournal of Pharmacological Sciences
Volume92
Issue number1
Publication statusPublished - May 1 2003

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lymphocyte Function-Associated Antigen-1
Intercellular Adhesion Molecule-1
Histamine
Inflammation
Monocytes
Dinoprostone
Cell Communication
Catecholamines
Norepinephrine
B7 Antigens
Histamine Agonists
Histidine Decarboxylase
Basophils
Adenylyl Cyclases
Innate Immunity
Mast Cells
Prostaglandins
Macrophages
Lymphocytes

Keywords

  • Histamine
  • ICAM-1
  • LFA-1
  • Monocyte
  • Prostaglandin E

ASJC Scopus subject areas

  • Pharmacology

Cite this

The regulation of ICAM-1 and LFA-1 interaction by autocoids and statins : A novel strategy for controlling inflammation and immune responses. / Nishibori, Masahiro; Takahashi, Hideo K.; Mori, Shuji.

In: Journal of Pharmacological Sciences, Vol. 92, No. 1, 01.05.2003, p. 7-12.

Research output: Contribution to journalArticle

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