Abstract
A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 207-212 |
| Number of pages | 6 |
| Journal | Internal Medicine |
| Volume | 58 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 15 2019 |
| Externally published | Yes |
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Keywords
- Eradication therapy
- Esophagus
- Helicobacter pylori
- MALT
- Rituximab
ASJC Scopus subject areas
- Internal Medicine
Cite this
The progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy : A case report and discussion of therapeutic options. / Takeuchi, Yukari; Miyahara, Koji; Morito, Toshiaki; Okikawa, Yoshiko; Kunugasa, Hideaki; Moritou, Yuki; Higashi, Reiji; Kunihiro, Masaki; Nakagawa, Masahiro.
In: Internal Medicine, Vol. 58, No. 2, 15.01.2019, p. 207-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy
T2 - A case report and discussion of therapeutic options
AU - Takeuchi, Yukari
AU - Miyahara, Koji
AU - Morito, Toshiaki
AU - Okikawa, Yoshiko
AU - Kunugasa, Hideaki
AU - Moritou, Yuki
AU - Higashi, Reiji
AU - Kunihiro, Masaki
AU - Nakagawa, Masahiro
PY - 2019/1/15
Y1 - 2019/1/15
N2 - A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.
AB - A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.
KW - Eradication therapy
KW - Esophagus
KW - Helicobacter pylori
KW - MALT
KW - Rituximab
UR - http://www.scopus.com/inward/record.url?scp=85060015785&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060015785&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.1112-18
DO - 10.2169/internalmedicine.1112-18
M3 - Article
C2 - 30146577
AN - SCOPUS:85060015785
VL - 58
SP - 207
EP - 212
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 2
ER -