The progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy: A case report and discussion of therapeutic options

Yukari Takeuchi, Koji Miyahara, Toshiaki Morito, Yoshiko Okikawa, Hideaki Kunugasa, Yuki Moritou, Reiji Higashi, Masaki Kunihiro, Masahiro Nakagawa

Research output: Contribution to journalArticle


A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalInternal Medicine
Issue number2
Publication statusPublished - Jan 15 2019
Externally publishedYes



  • Eradication therapy
  • Esophagus
  • Helicobacter pylori
  • MALT
  • Rituximab

ASJC Scopus subject areas

  • Internal Medicine

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