The progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy: A case report and discussion of therapeutic options

Yukari Takeuchi, Koji Miyahara, Toshiaki Morito, Yoshiko Okikawa, Hideaki Kunugasa, Yuki Moritou, Reiji Higashi, Masaki Kunihiro, Masahiro Nakagawa

Research output: Contribution to journalArticle

Abstract

A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalInternal Medicine
Volume58
Issue number2
DOIs
Publication statusPublished - Jan 15 2019
Externally publishedYes

Fingerprint

Marginal Zone B-Cell Lymphoma
Helicobacter pylori
Esophagus
Lymph Nodes
Digestive System Endoscopy
Cardia
Therapeutics
Disease Progression
Stomach
Tomography
Biopsy
Esophageal Mucosa
Neoplasms

Keywords

  • Eradication therapy
  • Esophagus
  • Helicobacter pylori
  • MALT
  • Rituximab

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy : A case report and discussion of therapeutic options. / Takeuchi, Yukari; Miyahara, Koji; Morito, Toshiaki; Okikawa, Yoshiko; Kunugasa, Hideaki; Moritou, Yuki; Higashi, Reiji; Kunihiro, Masaki; Nakagawa, Masahiro.

In: Internal Medicine, Vol. 58, No. 2, 15.01.2019, p. 207-212.

Research output: Contribution to journalArticle

Takeuchi, Yukari ; Miyahara, Koji ; Morito, Toshiaki ; Okikawa, Yoshiko ; Kunugasa, Hideaki ; Moritou, Yuki ; Higashi, Reiji ; Kunihiro, Masaki ; Nakagawa, Masahiro. / The progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy : A case report and discussion of therapeutic options. In: Internal Medicine. 2019 ; Vol. 58, No. 2. pp. 207-212.
@article{558abffe954547248e4fcc8e15d3f1c2,
title = "The progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy: A case report and discussion of therapeutic options",
abstract = "A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.",
keywords = "Eradication therapy, Esophagus, Helicobacter pylori, MALT, Rituximab",
author = "Yukari Takeuchi and Koji Miyahara and Toshiaki Morito and Yoshiko Okikawa and Hideaki Kunugasa and Yuki Moritou and Reiji Higashi and Masaki Kunihiro and Masahiro Nakagawa",
year = "2019",
month = "1",
day = "15",
doi = "10.2169/internalmedicine.1112-18",
language = "English",
volume = "58",
pages = "207--212",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "2",

}

TY - JOUR

T1 - The progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy

T2 - A case report and discussion of therapeutic options

AU - Takeuchi, Yukari

AU - Miyahara, Koji

AU - Morito, Toshiaki

AU - Okikawa, Yoshiko

AU - Kunugasa, Hideaki

AU - Moritou, Yuki

AU - Higashi, Reiji

AU - Kunihiro, Masaki

AU - Nakagawa, Masahiro

PY - 2019/1/15

Y1 - 2019/1/15

N2 - A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.

AB - A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.

KW - Eradication therapy

KW - Esophagus

KW - Helicobacter pylori

KW - MALT

KW - Rituximab

UR - http://www.scopus.com/inward/record.url?scp=85060015785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060015785&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.1112-18

DO - 10.2169/internalmedicine.1112-18

M3 - Article

C2 - 30146577

AN - SCOPUS:85060015785

VL - 58

SP - 207

EP - 212

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 2

ER -