Abstract
BACKGROUND/AIM: This study evaluated the associations between bone invasion of gingival squamous cell carcinoma (SCC) and clinicopathological manifestations, and aimed to determine whether bone invasion is an independent prognostic factor in gingival SCC.
RESULTS: Cortical and medullary bone invasion was present in 29 and 22 patients, respectively. There was a significant association between medullary bone invasion and tumor size (p=0.017), pathological N classification (p<0.001), differentiation (p=0.017) and lymphovascular invasion (p=0.007). Medullary bone invasion and lymphovascular invasion were independent predictors of reduced overall survival (p=0.015, 0.048); medullary bone invasion was also an independent predictor of reduced disease-specific survival (p=0.018).
PATIENTS AND METHODS: The study was a retrospective review of 78 patients with gingival SCC who underwent surgery with curative intent. The level of bone invasion was pathologically categorized as medullary, cortical or no bone invasion.
CONCLUSION: Pathologically-proven medullary bone invasion and lymphovascular invasion were found to be key prognostic factors in gingival SCC. The results suggest that it is necessary to consider adjuvant therapy in patients with medullary bone invasion.
| Original language | English |
|---|---|
| Pages (from-to) | 955-962 |
| Number of pages | 8 |
| Journal | Anticancer Research |
| Volume | 38 |
| Issue number | 2 |
| Publication status | Published - Feb 1 2018 |
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Keywords
- bone invasion
- Gingival squamous cell carcinoma
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma. / Yoshida, Shoko; Shimo, Tsuyoshi; Murase, Yurika; Takabatake, Kiyofumi; Kishimoto, Koji; Ibaragi, Soichiro; Yoshioka, Norie; Okui, Tatsuo; Nagatsuka, Hitoshi; Sasaki, Akira.
In: Anticancer Research, Vol. 38, No. 2, 01.02.2018, p. 955-962.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma
AU - Yoshida, Shoko
AU - Shimo, Tsuyoshi
AU - Murase, Yurika
AU - Takabatake, Kiyofumi
AU - Kishimoto, Koji
AU - Ibaragi, Soichiro
AU - Yoshioka, Norie
AU - Okui, Tatsuo
AU - Nagatsuka, Hitoshi
AU - Sasaki, Akira
PY - 2018/2/1
Y1 - 2018/2/1
N2 - BACKGROUND/AIM: This study evaluated the associations between bone invasion of gingival squamous cell carcinoma (SCC) and clinicopathological manifestations, and aimed to determine whether bone invasion is an independent prognostic factor in gingival SCC.RESULTS: Cortical and medullary bone invasion was present in 29 and 22 patients, respectively. There was a significant association between medullary bone invasion and tumor size (p=0.017), pathological N classification (p<0.001), differentiation (p=0.017) and lymphovascular invasion (p=0.007). Medullary bone invasion and lymphovascular invasion were independent predictors of reduced overall survival (p=0.015, 0.048); medullary bone invasion was also an independent predictor of reduced disease-specific survival (p=0.018).PATIENTS AND METHODS: The study was a retrospective review of 78 patients with gingival SCC who underwent surgery with curative intent. The level of bone invasion was pathologically categorized as medullary, cortical or no bone invasion.CONCLUSION: Pathologically-proven medullary bone invasion and lymphovascular invasion were found to be key prognostic factors in gingival SCC. The results suggest that it is necessary to consider adjuvant therapy in patients with medullary bone invasion.
AB - BACKGROUND/AIM: This study evaluated the associations between bone invasion of gingival squamous cell carcinoma (SCC) and clinicopathological manifestations, and aimed to determine whether bone invasion is an independent prognostic factor in gingival SCC.RESULTS: Cortical and medullary bone invasion was present in 29 and 22 patients, respectively. There was a significant association between medullary bone invasion and tumor size (p=0.017), pathological N classification (p<0.001), differentiation (p=0.017) and lymphovascular invasion (p=0.007). Medullary bone invasion and lymphovascular invasion were independent predictors of reduced overall survival (p=0.015, 0.048); medullary bone invasion was also an independent predictor of reduced disease-specific survival (p=0.018).PATIENTS AND METHODS: The study was a retrospective review of 78 patients with gingival SCC who underwent surgery with curative intent. The level of bone invasion was pathologically categorized as medullary, cortical or no bone invasion.CONCLUSION: Pathologically-proven medullary bone invasion and lymphovascular invasion were found to be key prognostic factors in gingival SCC. The results suggest that it is necessary to consider adjuvant therapy in patients with medullary bone invasion.
KW - bone invasion
KW - Gingival squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85041692953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041692953&partnerID=8YFLogxK
M3 - Article
C2 - 29374727
AN - SCOPUS:85041692953
VL - 38
SP - 955
EP - 962
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 2
ER -