TY - JOUR
T1 - The prognostic implications of bone invasion in gingival squamous cell Carcinoma
AU - Yoshida, Shoko
AU - Shimo, Tsuyoshi
AU - Murase, Yurika
AU - Takabatake, Kiyofumi
AU - Kishimoto, Koji
AU - Ibaragi, Soichiro
AU - Yoshioka, Norie
AU - Okui, Tatsuo
AU - Nagatsuka, Hitoshi
AU - Sasaki, Akira
N1 - Funding Information:
This work was partly supported by a Grant-in-Aid for Scientific Research (B) (#JP26293428 to T.S.) and Grant-in-Aid for Young Scientists (B) (#JP16K20579 to S.Y.) from Japan Society for the promotion of Sciences, Japan.
Publisher Copyright:
© 2018 International Institute of Anticancer Research. All rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - Background/Aim: This study evaluated the associations between bone invasion of gingival squamous cell carcinoma (SCC) and clinicopathological manifestations, and aimed to determine whether bone invasion is an independent prognostic factor in gingival SCC. Patients and Methods: The study was a retrospective review of 78 patients with gingival SCC who underwent surgery with curative intent. The level of bone invasion was pathologically categorized as medullary, cortical or no bone invasion. Results: Cortical and medullary bone invasion was present in 29 and 22 patients, respectively. There was a significant association between medullary bone invasion and tumor size (p=0.017), pathological N classification (p0.001), differentiation (p=0.017) and lymphovascular invasion (p=0.007). Medullary bone invasion and lymphovascular invasion were independent predictors of reduced overall survival (p=0.015, 0.048); medullary bone invasion was also an independent predictor of reduced disease-specific survival (p=0.018). Conclusion: Pathologically-proven medullary bone invasion and lymphovascular invasion were found to be key prognostic factors in gingival SCC. The results suggest that it is necessary to consider adjuvant therapy in patients with medullary bone invasion.
AB - Background/Aim: This study evaluated the associations between bone invasion of gingival squamous cell carcinoma (SCC) and clinicopathological manifestations, and aimed to determine whether bone invasion is an independent prognostic factor in gingival SCC. Patients and Methods: The study was a retrospective review of 78 patients with gingival SCC who underwent surgery with curative intent. The level of bone invasion was pathologically categorized as medullary, cortical or no bone invasion. Results: Cortical and medullary bone invasion was present in 29 and 22 patients, respectively. There was a significant association between medullary bone invasion and tumor size (p=0.017), pathological N classification (p0.001), differentiation (p=0.017) and lymphovascular invasion (p=0.007). Medullary bone invasion and lymphovascular invasion were independent predictors of reduced overall survival (p=0.015, 0.048); medullary bone invasion was also an independent predictor of reduced disease-specific survival (p=0.018). Conclusion: Pathologically-proven medullary bone invasion and lymphovascular invasion were found to be key prognostic factors in gingival SCC. The results suggest that it is necessary to consider adjuvant therapy in patients with medullary bone invasion.
KW - Gingival squamous cell carcinoma, bone invasion
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U2 - 10.21873/anticanres.12309
DO - 10.21873/anticanres.12309
M3 - Article
C2 - 29374727
AN - SCOPUS:85041692953
VL - 38
SP - 955
EP - 962
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 2
ER -
