Abstract
Background: Osteosarcoma as second malignancy of childhood cancers rarely occurs, and its clinical characteristics are unclear. Methods: Patients with osteosarcoma occurring as second malignancy of childhood cancers were retrospectively surveyed. Results: Of 323 patients with osteosarcoma registered in the database, 10 (3.1 %) had a past history of childhood cancers. The mean age at the onset of the first childhood cancer was 2.7 years, and the diagnosis of the first childhood cancer was adrenocortical carcinoma, malignant teratoma, ovarian carcinoma, Ewing’s sarcoma, and rhabdomyosarcoma in 1 patient each, and retinoblastoma in 5 patients. Osteosarcoma as second malignancy occurred 14.6 years after the first childhood cancer on average. Seven patients were alive and 3 died. In 1 patient, the cause of death was related to a complication of treatment for the first childhood cancer. Except for this patient, 7 (77.8 %) of 9 patients survived with no disease (mean follow-up period: 10.9 years). Conclusions: Attention should be paid to complications of treatment for the first childhood cancer in the treatment for osteosarcoma occurring as second malignancy. The prognosis of osteosarcoma as second malignancy of childhood cancers may be more favorable than that of conventional osteosarcoma.
| Original language | English |
|---|---|
| Pages (from-to) | 613-616 |
| Number of pages | 4 |
| Journal | International Journal of Clinical Oncology |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 11 2015 |
| Externally published | Yes |
Fingerprint
Keywords
- Childhood cancer
- Multiple primary cancers
- Osteosarcoma
- Second malignant neoplasm
ASJC Scopus subject areas
- Oncology
- Surgery
- Hematology
Cite this
The prognosis of osteosarcoma occurring as second malignancy of childhood cancers may be favorable : experience of two cancer centers in Japan. / Yonemoto, Tsukasa; Hosono, Ako; Iwata, Shintaro; Kamoda, Hiroto; Hagiwara, Yoko; Fujiwara, Tomohiro; Kawai, Akira; Ishii, Takeshi.
In: International Journal of Clinical Oncology, Vol. 20, No. 3, 11.06.2015, p. 613-616.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The prognosis of osteosarcoma occurring as second malignancy of childhood cancers may be favorable
T2 - experience of two cancer centers in Japan
AU - Yonemoto, Tsukasa
AU - Hosono, Ako
AU - Iwata, Shintaro
AU - Kamoda, Hiroto
AU - Hagiwara, Yoko
AU - Fujiwara, Tomohiro
AU - Kawai, Akira
AU - Ishii, Takeshi
PY - 2015/6/11
Y1 - 2015/6/11
N2 - Background: Osteosarcoma as second malignancy of childhood cancers rarely occurs, and its clinical characteristics are unclear. Methods: Patients with osteosarcoma occurring as second malignancy of childhood cancers were retrospectively surveyed. Results: Of 323 patients with osteosarcoma registered in the database, 10 (3.1 %) had a past history of childhood cancers. The mean age at the onset of the first childhood cancer was 2.7 years, and the diagnosis of the first childhood cancer was adrenocortical carcinoma, malignant teratoma, ovarian carcinoma, Ewing’s sarcoma, and rhabdomyosarcoma in 1 patient each, and retinoblastoma in 5 patients. Osteosarcoma as second malignancy occurred 14.6 years after the first childhood cancer on average. Seven patients were alive and 3 died. In 1 patient, the cause of death was related to a complication of treatment for the first childhood cancer. Except for this patient, 7 (77.8 %) of 9 patients survived with no disease (mean follow-up period: 10.9 years). Conclusions: Attention should be paid to complications of treatment for the first childhood cancer in the treatment for osteosarcoma occurring as second malignancy. The prognosis of osteosarcoma as second malignancy of childhood cancers may be more favorable than that of conventional osteosarcoma.
AB - Background: Osteosarcoma as second malignancy of childhood cancers rarely occurs, and its clinical characteristics are unclear. Methods: Patients with osteosarcoma occurring as second malignancy of childhood cancers were retrospectively surveyed. Results: Of 323 patients with osteosarcoma registered in the database, 10 (3.1 %) had a past history of childhood cancers. The mean age at the onset of the first childhood cancer was 2.7 years, and the diagnosis of the first childhood cancer was adrenocortical carcinoma, malignant teratoma, ovarian carcinoma, Ewing’s sarcoma, and rhabdomyosarcoma in 1 patient each, and retinoblastoma in 5 patients. Osteosarcoma as second malignancy occurred 14.6 years after the first childhood cancer on average. Seven patients were alive and 3 died. In 1 patient, the cause of death was related to a complication of treatment for the first childhood cancer. Except for this patient, 7 (77.8 %) of 9 patients survived with no disease (mean follow-up period: 10.9 years). Conclusions: Attention should be paid to complications of treatment for the first childhood cancer in the treatment for osteosarcoma occurring as second malignancy. The prognosis of osteosarcoma as second malignancy of childhood cancers may be more favorable than that of conventional osteosarcoma.
KW - Childhood cancer
KW - Multiple primary cancers
KW - Osteosarcoma
KW - Second malignant neoplasm
UR - http://www.scopus.com/inward/record.url?scp=84930621318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930621318&partnerID=8YFLogxK
U2 - 10.1007/s10147-014-0729-8
DO - 10.1007/s10147-014-0729-8
M3 - Article
C2 - 25022788
AN - SCOPUS:84930621318
VL - 20
SP - 613
EP - 616
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
SN - 1341-9625
IS - 3
ER -