The preventive effect of cyclosporin A, an immunosuppressant, on the late onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia

Norio Ogawa, Ken ichi Tanaka, Yoichi Kondo, Masato Asanuma, Kiminao Mizukawa, Akitane Mori

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We previously reported that a late onset reduction of muscarinic acetylcholine receptors (LORMAR) occurs in the gerbil hippocampus after 5 min of transient ischemia. This reduction begins as late as 7 days post-ischemia and accompanies the accumulation of glia, but is subsequent to completion of the disappearance of CA1 pyramidal cells. In the present study, we showed that this LORMAR was prevented by daily post-ischemic administration of the immunosuppressant cyclosporin A (CsA). The effectiveness of CsA against the LORMAR indicates that an immune mechanism may be involved in the progressive brain damage occurring after transient ischemia.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalNeuroscience Letters
Volume152
Issue number1-2
DOIs
Publication statusPublished - Apr 2 1993

Keywords

  • Cyclosporin A
  • Gerbil
  • Immunosuppressant
  • Late onset damage
  • Muscarinic acetylcholine receptor
  • Preventive therapy
  • Transient forebrain ischemia

ASJC Scopus subject areas

  • Neuroscience(all)

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