Abstract
Porcine edema disease (ED) is caused by Shiga toxin 2e-producing Escherichia coli (STEC). Post-weaned piglets often suffer from ED as a result of intestinal infection with STEC, which causes impaired growth performance and high mortality. Antimicrobial therapy is a curative treatment for piglets infected with STEC, but the emergence of antimicrobial-resistant STEC has become a serious problem for Japanese pig farmers. Therefore, an alternative strategy other than antimicrobial therapy is needed for the prevention or treatment of ED. In this study, we evaluated the effect of oral administration of Bacillus subtilisDB9011 (DB9011) to prevent the experimental infection of STEC in weaning piglets. Eight 21-day-old piglets were divided into two groups: STEC challenge with the basal diet, and STEC challenge with DB9011 supplemented diet. The challenge was carried out when the animals were 25, 26 and 27 days old using STEC contained in capsules resistant against gastric digestion. All pigs were euthanized at 36 days of age. DB9011 improved the symptoms of ED and decreased the number of STEC in the ileal digesta and feces. Accordingly, oral administration of DB9011 in weaned piglets prevents ED through the suppression of the growth of STEC in the ileum.
| Original language | English |
|---|---|
| Pages (from-to) | 316-321 |
| Number of pages | 6 |
| Journal | Animal Science Journal |
| Volume | 84 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2013 |
| Externally published | Yes |
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Keywords
- Bacillus subtilus strain DB9011
- Porcine edema disease
- Shiga toxin 2e-producing Escherichia coli
- Weaning pig
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
Cite this
The preventive effect of Bacillus subtilus strain DB9011 against experimental infection with enterotoxcemic Escherichia coli in weaning piglets. / Tsukahara, Takamitsu; Tsuruta, Takeshi; Nakanishi, Nobuo; Hikita, Chie; Mochizuki, Masami; Nakayama, Keizo.
In: Animal Science Journal, Vol. 84, No. 4, 04.2013, p. 316-321.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The preventive effect of Bacillus subtilus strain DB9011 against experimental infection with enterotoxcemic Escherichia coli in weaning piglets
AU - Tsukahara, Takamitsu
AU - Tsuruta, Takeshi
AU - Nakanishi, Nobuo
AU - Hikita, Chie
AU - Mochizuki, Masami
AU - Nakayama, Keizo
PY - 2013/4
Y1 - 2013/4
N2 - Porcine edema disease (ED) is caused by Shiga toxin 2e-producing Escherichia coli (STEC). Post-weaned piglets often suffer from ED as a result of intestinal infection with STEC, which causes impaired growth performance and high mortality. Antimicrobial therapy is a curative treatment for piglets infected with STEC, but the emergence of antimicrobial-resistant STEC has become a serious problem for Japanese pig farmers. Therefore, an alternative strategy other than antimicrobial therapy is needed for the prevention or treatment of ED. In this study, we evaluated the effect of oral administration of Bacillus subtilisDB9011 (DB9011) to prevent the experimental infection of STEC in weaning piglets. Eight 21-day-old piglets were divided into two groups: STEC challenge with the basal diet, and STEC challenge with DB9011 supplemented diet. The challenge was carried out when the animals were 25, 26 and 27 days old using STEC contained in capsules resistant against gastric digestion. All pigs were euthanized at 36 days of age. DB9011 improved the symptoms of ED and decreased the number of STEC in the ileal digesta and feces. Accordingly, oral administration of DB9011 in weaned piglets prevents ED through the suppression of the growth of STEC in the ileum.
AB - Porcine edema disease (ED) is caused by Shiga toxin 2e-producing Escherichia coli (STEC). Post-weaned piglets often suffer from ED as a result of intestinal infection with STEC, which causes impaired growth performance and high mortality. Antimicrobial therapy is a curative treatment for piglets infected with STEC, but the emergence of antimicrobial-resistant STEC has become a serious problem for Japanese pig farmers. Therefore, an alternative strategy other than antimicrobial therapy is needed for the prevention or treatment of ED. In this study, we evaluated the effect of oral administration of Bacillus subtilisDB9011 (DB9011) to prevent the experimental infection of STEC in weaning piglets. Eight 21-day-old piglets were divided into two groups: STEC challenge with the basal diet, and STEC challenge with DB9011 supplemented diet. The challenge was carried out when the animals were 25, 26 and 27 days old using STEC contained in capsules resistant against gastric digestion. All pigs were euthanized at 36 days of age. DB9011 improved the symptoms of ED and decreased the number of STEC in the ileal digesta and feces. Accordingly, oral administration of DB9011 in weaned piglets prevents ED through the suppression of the growth of STEC in the ileum.
KW - Bacillus subtilus strain DB9011
KW - Porcine edema disease
KW - Shiga toxin 2e-producing Escherichia coli
KW - Weaning pig
UR - http://www.scopus.com/inward/record.url?scp=84876733745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876733745&partnerID=8YFLogxK
U2 - 10.1111/asj.12003
DO - 10.1111/asj.12003
M3 - Article
C2 - 23590505
AN - SCOPUS:84876733745
VL - 84
SP - 316
EP - 321
JO - Animal Science Journal
JF - Animal Science Journal
SN - 1344-3941
IS - 4
ER -