The preventive effect of Bacillus subtilus strain DB9011 against experimental infection with enterotoxcemic Escherichia coli in weaning piglets

Takamitsu Tsukahara, Takeshi Tsuruta, Nobuo Nakanishi, Chie Hikita, Masami Mochizuki, Keizo Nakayama

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Porcine edema disease (ED) is caused by Shiga toxin 2e-producing Escherichia coli (STEC). Post-weaned piglets often suffer from ED as a result of intestinal infection with STEC, which causes impaired growth performance and high mortality. Antimicrobial therapy is a curative treatment for piglets infected with STEC, but the emergence of antimicrobial-resistant STEC has become a serious problem for Japanese pig farmers. Therefore, an alternative strategy other than antimicrobial therapy is needed for the prevention or treatment of ED. In this study, we evaluated the effect of oral administration of Bacillus subtilisDB9011 (DB9011) to prevent the experimental infection of STEC in weaning piglets. Eight 21-day-old piglets were divided into two groups: STEC challenge with the basal diet, and STEC challenge with DB9011 supplemented diet. The challenge was carried out when the animals were 25, 26 and 27 days old using STEC contained in capsules resistant against gastric digestion. All pigs were euthanized at 36 days of age. DB9011 improved the symptoms of ED and decreased the number of STEC in the ileal digesta and feces. Accordingly, oral administration of DB9011 in weaned piglets prevents ED through the suppression of the growth of STEC in the ileum.

Original languageEnglish
Pages (from-to)316-321
Number of pages6
JournalAnimal Science Journal
Volume84
Issue number4
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

Fingerprint

Shiga-Toxigenic Escherichia coli
Shiga toxin-producing Escherichia coli
Weaning
Bacillus
piglets
weaning
Escherichia coli
Infection
infection
edema
Edema
oral administration
drug therapy
swine
Oral Administration
Swine
Swine Diseases
Diet
Therapeutics
Growth

Keywords

  • Bacillus subtilus strain DB9011
  • Porcine edema disease
  • Shiga toxin 2e-producing Escherichia coli
  • Weaning pig

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

The preventive effect of Bacillus subtilus strain DB9011 against experimental infection with enterotoxcemic Escherichia coli in weaning piglets. / Tsukahara, Takamitsu; Tsuruta, Takeshi; Nakanishi, Nobuo; Hikita, Chie; Mochizuki, Masami; Nakayama, Keizo.

In: Animal Science Journal, Vol. 84, No. 4, 04.2013, p. 316-321.

Research output: Contribution to journalArticle

Tsukahara, Takamitsu ; Tsuruta, Takeshi ; Nakanishi, Nobuo ; Hikita, Chie ; Mochizuki, Masami ; Nakayama, Keizo. / The preventive effect of Bacillus subtilus strain DB9011 against experimental infection with enterotoxcemic Escherichia coli in weaning piglets. In: Animal Science Journal. 2013 ; Vol. 84, No. 4. pp. 316-321.
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