The prevalence of frailty and its associated factors in Japanese hemodialysis patients

Hidemi Takeuchi, Haruhito Adam Uchida, Yuki Kakio, Yuka Okuyama, Michihiro Okuyama, Ryoko Umebayashi, Kentaro Wada, Hitoshi Sugiyama, Ken Sugimoto, Hiromi Rakugi, Jun Wada

Research output: Contribution to journalArticle

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Abstract

The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was to identify the prevalence and predictors of frailty in Japanese HD patients. This study was a multicenter, cross-sectional and observational investigation conducted at 6 institutions. To evaluate frailty, the modified Fried's frailty phenotype adjusted for Japanese as the self-reported questionnaire was used. Of the 542 patients visiting each institution, 388 were enrolled in this study. In total, 26.0% of participants were categorized as not-frailty, 52.6% as pre-frailty and 21.4% as frailty. The prevalence of frailty increased steadily with age and was more prevalent in females than in males and the subjects with frailty received polypharmacy. A multivariate logistic regression analysis revealed that the factors independently associated with frailty were the following: female gender (odds ratio [OR] = 3.661, 95% confidence interval [CI] 1.398-9.588), age (OR = 1.065, 95% CI 1.014-1.119), age ≥ 75 years old (OR = 4.892, 95% CI 1.715-13.955), body mass index (BMI) < 18.5 (OR = 0.110, 95% CI 0.0293-0.416), number of medications being taken (OR = 1.351, 95% CI 1.163-1.570), diabetes mellitus (DM) (OR = 2.765, 95% CI 1.081-7.071) and MNA-SF ≤ 11 (OR = 7.405, 95% CI 2.732-20.072). Frailty was associated with the accumulation of risk factors. The prevalence of frailty in Japanese patients with HD was relatively lower than that previously reported in Western developed countries; however, it was extremely high compared to the general population regardless of age. Our findings suggest that frailty might be associated with an increase in the prevalence of adverse health outcomes in patients with HD.

Original languageEnglish
Pages (from-to)192-207
Number of pages16
JournalAging and Disease
Volume9
Issue number2
DOIs
Publication statusPublished - Apr 1 2018

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Renal Dialysis
Odds Ratio
Confidence Intervals
Population
Polypharmacy
Developed Countries
Chronic Kidney Failure
Dialysis
Diabetes Mellitus
Japan
Body Mass Index
Logistic Models
Regression Analysis
Phenotype
Health

Keywords

  • Dialysis
  • Frailty
  • Frailty phenotype

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology

Cite this

The prevalence of frailty and its associated factors in Japanese hemodialysis patients. / Takeuchi, Hidemi; Uchida, Haruhito Adam; Kakio, Yuki; Okuyama, Yuka; Okuyama, Michihiro; Umebayashi, Ryoko; Wada, Kentaro; Sugiyama, Hitoshi; Sugimoto, Ken; Rakugi, Hiromi; Wada, Jun.

In: Aging and Disease, Vol. 9, No. 2, 01.04.2018, p. 192-207.

Research output: Contribution to journalArticle

Takeuchi, H, Uchida, HA, Kakio, Y, Okuyama, Y, Okuyama, M, Umebayashi, R, Wada, K, Sugiyama, H, Sugimoto, K, Rakugi, H & Wada, J 2018, 'The prevalence of frailty and its associated factors in Japanese hemodialysis patients', Aging and Disease, vol. 9, no. 2, pp. 192-207. https://doi.org/10.14336/AD.2017.0429
Takeuchi, Hidemi ; Uchida, Haruhito Adam ; Kakio, Yuki ; Okuyama, Yuka ; Okuyama, Michihiro ; Umebayashi, Ryoko ; Wada, Kentaro ; Sugiyama, Hitoshi ; Sugimoto, Ken ; Rakugi, Hiromi ; Wada, Jun. / The prevalence of frailty and its associated factors in Japanese hemodialysis patients. In: Aging and Disease. 2018 ; Vol. 9, No. 2. pp. 192-207.
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