The pretreatment of maximum standardized uptake values (SUVmax) of the primary tumor is predictor for poor prognosis for patients with epithelial ovarian cancer

Keiichiro Nakamura, Atsushi Hongo, Junichi Kodama, Yuji Hiramatsu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The purpose of this study was to evaluate prognostic factors for epithelial ovarian cancer. We found that the pretreatment values of maximum standardized uptake (SUVmax) of the primary tumor by positron emission tomography/computed tomography (PET/CT), tumor marker CA125 and C-reactive protein (CRP) were correlated with clinical characteristics and prognosis for such patients. The clinical parameters and prognoses and their correlations with SUVmax of primary tumor, CA125 and CRP were examined for 51 patients with primary ovarian cancer. The SUVmax of the primary tumor had a statistically significant association with stage (p = 0.010) and histology (p = 0.001). CA125 was significant associated with stage (p = 0. Oil), histology (p = 0.005) and lymph node metastasis (p=0.025). CRP was also significantly associated with stage (p = 0.049). Disease-free survival rates of patients exhibiting a high SUVmax, CA125 and CRP were significantly lower than those exhibiting a low SUVmax, CA125 and CRP levels (p = 0.008, 0.034, and 0.037, respectively). Furthermore, overall survival rates of patients exhibiting a high SUVmax were significantly lower than those exhibiting a low SUVmax (p = 0.049). The high SUVmax of primary tumor is an important factor for identifying ovarian cancer patients with a predictor for poor prognosis.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalActa medica Okayama
Volume66
Issue number1
Publication statusPublished - Feb 23 2012
Externally publishedYes

Keywords

  • C-reactive protein
  • CA125
  • Ovarian cancer
  • Predictor for poor prognosis
  • SUVmax of primary tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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