The predictive value of measurement of SUVmax and SCC-antigen in patients with pretreatment of primary squamous cell carcinoma of cervix

Keiichiro Nakamura, Yoshihiro Okumura, Junichi Kodama, Atsushi Hongo, Susumu Kanazawa, Yuji Hiramatsu

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: Use of positron emission tomography/computed tomography (PET/CT) and serum squamous cell carcinoma (SCC) antigen (SCC-ag) as predictors for poor prognosis of pretreatment of primary SCC of cervix. Methods: The distribution of cases that scored positive for each of the biological parameters examined was correlated with maximum SUV (SUVmax) of PET/CT and serum SCC-ag for 52 participants prior to radiotherapy (RT) with or without concurrent chemotherapy (CCRT) with pretreatment of primary SCC of cervix. Results: There were significant correlations between the SUVmax of the primary tumor and tumor maximum size (P = 0.027), and the lymph node metastasis (P = 0.039). The serum SCC-ag had a statistically significant association with the clinicopathological parameters such as FIGO stage (P = 0.045) and tumor maximum size (P = 0.008), although there was no correlation noted between the SUVmax of the primary tumor and the serum SCC-ag (R = 0.155). The high SUVmax of the primary tumor (? 15.6) plus lymph node metastasis (a short-axis diameter of over 10 mm with a SUVmax ? 3.5) were significant predictors for poor prognosis when compared with the low SUVmax of the primary tumor (<15.6) or the high SUVmax of the primary tumor plus negative lymph node metastasis (a short-axis diameter of under 10 mm or SUVmax <3.5) (overall survival rate; P = 0.0211). Conclusions: The present findings indicate that the high SUVmax of the primary tumor plus lymph node metastasis with pretreatment of primary SCC of cervix may be associated with a poor prognosis.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalGynecologic Oncology
Volume119
Issue number1
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Cervix Uteri
Squamous Cell Carcinoma
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Serum
squamous cell carcinoma-related antigen
Radiotherapy
Drug Therapy

Keywords

  • Cervical cancer
  • Positron emission tomography/computed tomography
  • Predictor for poor prognosis
  • Serum squamous cell carcinoma antigen
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Medicine(all)

Cite this

The predictive value of measurement of SUVmax and SCC-antigen in patients with pretreatment of primary squamous cell carcinoma of cervix. / Nakamura, Keiichiro; Okumura, Yoshihiro; Kodama, Junichi; Hongo, Atsushi; Kanazawa, Susumu; Hiramatsu, Yuji.

In: Gynecologic Oncology, Vol. 119, No. 1, 10.2010, p. 81-86.

Research output: Contribution to journalArticle

@article{661792c4e46241c186efb607239db89e,
title = "The predictive value of measurement of SUVmax and SCC-antigen in patients with pretreatment of primary squamous cell carcinoma of cervix",
abstract = "Objective: Use of positron emission tomography/computed tomography (PET/CT) and serum squamous cell carcinoma (SCC) antigen (SCC-ag) as predictors for poor prognosis of pretreatment of primary SCC of cervix. Methods: The distribution of cases that scored positive for each of the biological parameters examined was correlated with maximum SUV (SUVmax) of PET/CT and serum SCC-ag for 52 participants prior to radiotherapy (RT) with or without concurrent chemotherapy (CCRT) with pretreatment of primary SCC of cervix. Results: There were significant correlations between the SUVmax of the primary tumor and tumor maximum size (P = 0.027), and the lymph node metastasis (P = 0.039). The serum SCC-ag had a statistically significant association with the clinicopathological parameters such as FIGO stage (P = 0.045) and tumor maximum size (P = 0.008), although there was no correlation noted between the SUVmax of the primary tumor and the serum SCC-ag (R = 0.155). The high SUVmax of the primary tumor (? 15.6) plus lymph node metastasis (a short-axis diameter of over 10 mm with a SUVmax ? 3.5) were significant predictors for poor prognosis when compared with the low SUVmax of the primary tumor (<15.6) or the high SUVmax of the primary tumor plus negative lymph node metastasis (a short-axis diameter of under 10 mm or SUVmax <3.5) (overall survival rate; P = 0.0211). Conclusions: The present findings indicate that the high SUVmax of the primary tumor plus lymph node metastasis with pretreatment of primary SCC of cervix may be associated with a poor prognosis.",
keywords = "Cervical cancer, Positron emission tomography/computed tomography, Predictor for poor prognosis, Serum squamous cell carcinoma antigen, Squamous cell carcinoma",
author = "Keiichiro Nakamura and Yoshihiro Okumura and Junichi Kodama and Atsushi Hongo and Susumu Kanazawa and Yuji Hiramatsu",
year = "2010",
month = "10",
doi = "10.1016/j.ygyno.2010.04.020",
language = "English",
volume = "119",
pages = "81--86",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The predictive value of measurement of SUVmax and SCC-antigen in patients with pretreatment of primary squamous cell carcinoma of cervix

AU - Nakamura, Keiichiro

AU - Okumura, Yoshihiro

AU - Kodama, Junichi

AU - Hongo, Atsushi

AU - Kanazawa, Susumu

AU - Hiramatsu, Yuji

PY - 2010/10

Y1 - 2010/10

N2 - Objective: Use of positron emission tomography/computed tomography (PET/CT) and serum squamous cell carcinoma (SCC) antigen (SCC-ag) as predictors for poor prognosis of pretreatment of primary SCC of cervix. Methods: The distribution of cases that scored positive for each of the biological parameters examined was correlated with maximum SUV (SUVmax) of PET/CT and serum SCC-ag for 52 participants prior to radiotherapy (RT) with or without concurrent chemotherapy (CCRT) with pretreatment of primary SCC of cervix. Results: There were significant correlations between the SUVmax of the primary tumor and tumor maximum size (P = 0.027), and the lymph node metastasis (P = 0.039). The serum SCC-ag had a statistically significant association with the clinicopathological parameters such as FIGO stage (P = 0.045) and tumor maximum size (P = 0.008), although there was no correlation noted between the SUVmax of the primary tumor and the serum SCC-ag (R = 0.155). The high SUVmax of the primary tumor (? 15.6) plus lymph node metastasis (a short-axis diameter of over 10 mm with a SUVmax ? 3.5) were significant predictors for poor prognosis when compared with the low SUVmax of the primary tumor (<15.6) or the high SUVmax of the primary tumor plus negative lymph node metastasis (a short-axis diameter of under 10 mm or SUVmax <3.5) (overall survival rate; P = 0.0211). Conclusions: The present findings indicate that the high SUVmax of the primary tumor plus lymph node metastasis with pretreatment of primary SCC of cervix may be associated with a poor prognosis.

AB - Objective: Use of positron emission tomography/computed tomography (PET/CT) and serum squamous cell carcinoma (SCC) antigen (SCC-ag) as predictors for poor prognosis of pretreatment of primary SCC of cervix. Methods: The distribution of cases that scored positive for each of the biological parameters examined was correlated with maximum SUV (SUVmax) of PET/CT and serum SCC-ag for 52 participants prior to radiotherapy (RT) with or without concurrent chemotherapy (CCRT) with pretreatment of primary SCC of cervix. Results: There were significant correlations between the SUVmax of the primary tumor and tumor maximum size (P = 0.027), and the lymph node metastasis (P = 0.039). The serum SCC-ag had a statistically significant association with the clinicopathological parameters such as FIGO stage (P = 0.045) and tumor maximum size (P = 0.008), although there was no correlation noted between the SUVmax of the primary tumor and the serum SCC-ag (R = 0.155). The high SUVmax of the primary tumor (? 15.6) plus lymph node metastasis (a short-axis diameter of over 10 mm with a SUVmax ? 3.5) were significant predictors for poor prognosis when compared with the low SUVmax of the primary tumor (<15.6) or the high SUVmax of the primary tumor plus negative lymph node metastasis (a short-axis diameter of under 10 mm or SUVmax <3.5) (overall survival rate; P = 0.0211). Conclusions: The present findings indicate that the high SUVmax of the primary tumor plus lymph node metastasis with pretreatment of primary SCC of cervix may be associated with a poor prognosis.

KW - Cervical cancer

KW - Positron emission tomography/computed tomography

KW - Predictor for poor prognosis

KW - Serum squamous cell carcinoma antigen

KW - Squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=77956648591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956648591&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2010.04.020

DO - 10.1016/j.ygyno.2010.04.020

M3 - Article

VL - 119

SP - 81

EP - 86

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 1

ER -