The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells

Colette A. Inkson, Mitsuaki Ono, Yanming Bi, Sergei A. Kuznetsov, Larry W. Fisher, Marian F. Young

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Biglycan (BGN) and WISP-1 are 2 extracellular matrix proteins that bind to each other and colocalize in mineralizing tissue. Here we show that WISP-1 abrogates the repression of proliferation in bone marrow stromal cells induced by BGN. We also demonstrate that WISP-1 and its variant WISP-1va can alleviate the repressed osteogenic differentiation caused by the absence of BGN. These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other's activity, thus regulating the differentiation and proliferation of osteogenic cells.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalCells Tissues Organs
Volume189
Issue number1-4
DOIs
Publication statusPublished - Dec 1 2008
Externally publishedYes

Keywords

  • Biglycan
  • Osteogenesis
  • Proliferation
  • WISP-1/CCN4
  • WISP-1va

ASJC Scopus subject areas

  • Anatomy
  • Histology

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