The pharmacological activity of cannabinol and its major metabolite, 11-hydroxycannabinol

Ikuo Yamamoto; Kazuhito Watanabe; Katsunori Kuzuoka; Shizuo Narimatsu; Hidetoshi Yoshimura

doi:10.1248/cpb.35.2144

The pharmacological activity of cannabinol and its major metabolite, 11-hydroxycannabinol

Ikuo Yamamoto, Kazuhito Watanabe, Katsunori Kuzuoka, Shizuo Narimatsu, Hidetoshi Yoshimura

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation and effect on locomotor activity) of cannabinol and its major metabolite, 11-hydroxycannabinol were studied in mice. 11-Hydroxycannabinol was more potent than cannabinol in the pharmacological indices examined. The results indicate that 11-hydroxycannabinol can be categorized as an active metabolite of cannabinol.

Original language	English
Pages (from-to)	2144-2147
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	35
Issue number	5
DOIs	https://doi.org/10.1248/cpb.35.2144
Publication status	Published - Jan 1 1987

Keywords

11-hydroxycannabinol
active metabolite
cannabinol
catalepsy
hypothermia
locomotor activity
pentobarbital-induced sleep

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.35.2144

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abstract = "The pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation and effect on locomotor activity) of cannabinol and its major metabolite, 11-hydroxycannabinol were studied in mice. 11-Hydroxycannabinol was more potent than cannabinol in the pharmacological indices examined. The results indicate that 11-hydroxycannabinol can be categorized as an active metabolite of cannabinol.",

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AU - Yoshimura, Hidetoshi

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The pharmacological activity of cannabinol and its major metabolite, 11-hydroxycannabinol

Abstract

Keywords

ASJC Scopus subject areas

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