The pharmacological activity of cannabinol and its major metabolite, 11-hydroxycannabinol

Ikuo Yamamoto, Kazuhito Watanabe, Katsunori Kuzuoka, Shizuo Narimatsu, Hidetoshi Yoshimura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation and effect on locomotor activity) of cannabinol and its major metabolite, 11-hydroxycannabinol were studied in mice. 11-Hydroxycannabinol was more potent than cannabinol in the pharmacological indices examined. The results indicate that 11-hydroxycannabinol can be categorized as an active metabolite of cannabinol.

Original languageEnglish
Pages (from-to)2144-2147
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume35
Issue number5
DOIs
Publication statusPublished - Jan 1 1987

Keywords

  • 11-hydroxycannabinol
  • active metabolite
  • cannabinol
  • catalepsy
  • hypothermia
  • locomotor activity
  • pentobarbital-induced sleep

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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