The pathophysiology of heterotopic ossification: Current treatment considerations in dentistry

Kengo Shimono, Kenta Uchibe, Takuo Kuboki, Masahiro Iwamoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Heterotopic ossification (HO) consists of the formation of ectopic cartilage followed by endochondral bone, and is triggered by major surgeries, large wounds, and other conditions. Daily functions of HO patients can be hampered by the loss of normal posture, pain, inflammation, reduced mobility, formation of pressure ulcers, deep venous thrombosis, and other complications. Research so far revealed the molecular and cellular pathways leading HO formation, and proposed several possible mechanisms behind such pathways. Nonsteroidal anti-inflammatory drug (NSAID) regimens and localized low-dose irradiation are currently available as prophylaxis of HO formation. However, they are not always effective and do not target skeletogenic processes directly. New therapeutic modalities targeting pathological process of HO formation, such as bone morphogenetic proteins (BMP) inhibitors like Noggin, BMP type 1 receptor inhibitor, and nuclear retinoic acid receptor-gamma (RARγ) agonists are currently under investigation. In this review, we will summarize our current understanding of the pathology and molecular and cellular mechanisms of HO, especially endochondral heterotopic ossification, and then discuss its current and future therapies. We will also discuss the potential application of heterotopic ossification in the dental field.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJapanese Dental Science Review
Volume50
Issue number1
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Heterotopic Ossification
Dentistry
Therapeutics
Type I Bone Morphogenetic Protein Receptors
Bone Morphogenetic Proteins
Molecular Pathology
Pressure Ulcer
Pathologic Processes
Posture
Osteogenesis
Venous Thrombosis
Cartilage
Tooth
Anti-Inflammatory Agents
Inflammation
Bone and Bones
Pain
Wounds and Injuries

Keywords

  • Bone regeneration
  • Dentistry
  • Heterotopic ossification
  • RARγ agonist

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

The pathophysiology of heterotopic ossification : Current treatment considerations in dentistry. / Shimono, Kengo; Uchibe, Kenta; Kuboki, Takuo; Iwamoto, Masahiro.

In: Japanese Dental Science Review, Vol. 50, No. 1, 02.2014, p. 1-8.

Research output: Contribution to journalArticle

@article{785355bf87c246e68f1ed2982005e09c,
title = "The pathophysiology of heterotopic ossification: Current treatment considerations in dentistry",
abstract = "Heterotopic ossification (HO) consists of the formation of ectopic cartilage followed by endochondral bone, and is triggered by major surgeries, large wounds, and other conditions. Daily functions of HO patients can be hampered by the loss of normal posture, pain, inflammation, reduced mobility, formation of pressure ulcers, deep venous thrombosis, and other complications. Research so far revealed the molecular and cellular pathways leading HO formation, and proposed several possible mechanisms behind such pathways. Nonsteroidal anti-inflammatory drug (NSAID) regimens and localized low-dose irradiation are currently available as prophylaxis of HO formation. However, they are not always effective and do not target skeletogenic processes directly. New therapeutic modalities targeting pathological process of HO formation, such as bone morphogenetic proteins (BMP) inhibitors like Noggin, BMP type 1 receptor inhibitor, and nuclear retinoic acid receptor-gamma (RARγ) agonists are currently under investigation. In this review, we will summarize our current understanding of the pathology and molecular and cellular mechanisms of HO, especially endochondral heterotopic ossification, and then discuss its current and future therapies. We will also discuss the potential application of heterotopic ossification in the dental field.",
keywords = "Bone regeneration, Dentistry, Heterotopic ossification, RARγ agonist",
author = "Kengo Shimono and Kenta Uchibe and Takuo Kuboki and Masahiro Iwamoto",
year = "2014",
month = "2",
doi = "10.1016/j.jdsr.2013.07.003",
language = "English",
volume = "50",
pages = "1--8",
journal = "Japanese Dental Science Review",
issn = "1882-7616",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - The pathophysiology of heterotopic ossification

T2 - Current treatment considerations in dentistry

AU - Shimono, Kengo

AU - Uchibe, Kenta

AU - Kuboki, Takuo

AU - Iwamoto, Masahiro

PY - 2014/2

Y1 - 2014/2

N2 - Heterotopic ossification (HO) consists of the formation of ectopic cartilage followed by endochondral bone, and is triggered by major surgeries, large wounds, and other conditions. Daily functions of HO patients can be hampered by the loss of normal posture, pain, inflammation, reduced mobility, formation of pressure ulcers, deep venous thrombosis, and other complications. Research so far revealed the molecular and cellular pathways leading HO formation, and proposed several possible mechanisms behind such pathways. Nonsteroidal anti-inflammatory drug (NSAID) regimens and localized low-dose irradiation are currently available as prophylaxis of HO formation. However, they are not always effective and do not target skeletogenic processes directly. New therapeutic modalities targeting pathological process of HO formation, such as bone morphogenetic proteins (BMP) inhibitors like Noggin, BMP type 1 receptor inhibitor, and nuclear retinoic acid receptor-gamma (RARγ) agonists are currently under investigation. In this review, we will summarize our current understanding of the pathology and molecular and cellular mechanisms of HO, especially endochondral heterotopic ossification, and then discuss its current and future therapies. We will also discuss the potential application of heterotopic ossification in the dental field.

AB - Heterotopic ossification (HO) consists of the formation of ectopic cartilage followed by endochondral bone, and is triggered by major surgeries, large wounds, and other conditions. Daily functions of HO patients can be hampered by the loss of normal posture, pain, inflammation, reduced mobility, formation of pressure ulcers, deep venous thrombosis, and other complications. Research so far revealed the molecular and cellular pathways leading HO formation, and proposed several possible mechanisms behind such pathways. Nonsteroidal anti-inflammatory drug (NSAID) regimens and localized low-dose irradiation are currently available as prophylaxis of HO formation. However, they are not always effective and do not target skeletogenic processes directly. New therapeutic modalities targeting pathological process of HO formation, such as bone morphogenetic proteins (BMP) inhibitors like Noggin, BMP type 1 receptor inhibitor, and nuclear retinoic acid receptor-gamma (RARγ) agonists are currently under investigation. In this review, we will summarize our current understanding of the pathology and molecular and cellular mechanisms of HO, especially endochondral heterotopic ossification, and then discuss its current and future therapies. We will also discuss the potential application of heterotopic ossification in the dental field.

KW - Bone regeneration

KW - Dentistry

KW - Heterotopic ossification

KW - RARγ agonist

UR - http://www.scopus.com/inward/record.url?scp=84892545558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892545558&partnerID=8YFLogxK

U2 - 10.1016/j.jdsr.2013.07.003

DO - 10.1016/j.jdsr.2013.07.003

M3 - Article

AN - SCOPUS:84892545558

VL - 50

SP - 1

EP - 8

JO - Japanese Dental Science Review

JF - Japanese Dental Science Review

SN - 1882-7616

IS - 1

ER -