The outcome of living donor liver transplantation with prior spontaneous large portasystemic shunts

Hiroshi Sadamori, Takahito Yagi, Hiroyoshi Matsukawa, Hiroaki Matsuda, Susumu Shinoura, Yuzo Umeda, Takayuki Iwamoto, Daisuke Satoh, Noriaki Tanaka

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We investigated the outcome of living donor liver transplantation (LDLT) with prior spontaneous large portasystemic shunts. Thirty-three patients of 155 patients (21.2%) undergoing LDLT had spontaneous large portasystemic shunts. Portal venous hemodynamics, surgical procedures for shunts, and morbidity and mortality rates were investigated in three types of shunts: splenorenal shunt (SRS group; n = 11), shunt derived from coronary vein (CVS group; n = 6) and umbilical vein shunt (UVS group; n = 15). The two groups of patients (SRS/CVS) received prophylactic surgical repair of shunts during LDLT except for one patient in the SRS group. The flow direction of main portal vein and grade of steal of superior mesenteric vein flow by shunt were significantly different among three groups. No significant differences were observed among three groups in operative parameters, hospitalization and morbidity except for postoperative portal complication. There was no significant difference in the actuarial survival rate among three groups of SRS, CVS and UVS (81.8% vs. 83.3% vs. 86.6% at 1 year respectively). In the SRS group, two patients had postoperative steal of graft portal venous flow by residual SRS that needed further treatment. The outcome of LDLT with prior spontaneous large portasystemic shunts is satisfactory, despite the complexity of the transplant procedures.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalTransplant International
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Living donor liver transplantation
  • Morbidity
  • Portal venous hemodynamics
  • Portasystemic shunt
  • Splenorenal shunt

ASJC Scopus subject areas

  • Transplantation

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