The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice

H. Ichikawa, R. Terayama, T. Yamaai, Y. De Repentigny, R. Kothary, T. Sugimoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The trigeminal ganglion (TG) and mesencephalic trigeminal tract nucleus (Mes5) were investigated in wild type and dystonia musculorum (dt) mice to study the effect of dystonin deficiency on primary sensory neurons in the trigeminal nervous system. At postnatal day 14, the number of TG neurons was markedly decreased in dt mice when compared to wild type mice (43.1% reduction). In addition, dystonin disruption decreased the number of sensory neurons which bound to isolectin B4, and contained calcitonin gene-related peptide or high-affinity nerve growth factor receptor TrkA. Immunohistochemistry for caspase-3 demonstrated that dystonin deficiency induced excess cell death of TG neurons during the early postnatal period. In contrast, Mes5 neurons were barely affected in dt mice. These data together suggest that dystonin is necessary for survival of nociceptors but not proprioceptors in the trigeminal nervous system.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalBrain Research
Volume1226
DOIs
Publication statusPublished - Aug 21 2008

Fingerprint

Tegmentum Mesencephali
Trigeminal Ganglion
Nociceptors
Dystonia
Sensory Receptor Cells
Neurons
Nervous System
Nerve Growth Factor Receptor
Calcitonin Gene-Related Peptide
Lectins
Caspase 3
Cell Death
Immunohistochemistry
Dystonin

Keywords

  • Immunohistochemistry
  • Mesencephalic trigeminal tract nucleus
  • Mutant mouse
  • Neurochemical substance
  • Plakins
  • Sensory neuron
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice. / Ichikawa, H.; Terayama, R.; Yamaai, T.; De Repentigny, Y.; Kothary, R.; Sugimoto, T.

In: Brain Research, Vol. 1226, 21.08.2008, p. 33-38.

Research output: Contribution to journalArticle

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