The neurobiology of psychogenic erectile dysfunction in the spinal cord

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We recently reported a previously unknown peptidergic system within the lumbosacral spinal cord that uses gastrin-releasing peptide (GRP) to trigger erection and ejaculation inmale rats. Many men suffering from stress, including posttraumatic stress disorder (PTSD) and major depressive disorder, report sexual dysfunction. Sexual dysfunction in men suffering from stress and major depressive disorder is traditionally treated via psychological counseling. To determine whether acute severe stress could alter the male-specific GRP system, we used single prolonged stress (SPS) exposure in a putative rat model for PTSD. Exposure of male rats to SPS decreases the local content and the axonal distribution of GRP in the lower lumbar spinal cord and results in an attenuation of penile reflexes in vivo. Pharmacological stimulation of GRP receptors remarkably restores penile reflexes in SPS-exposed male rats and in castrated male rats. The administration of a GRP agonist to these animal models interestingly induces spontaneous ejaculation in a dose-dependent manner. Furthermore, although the circulating level of androgens is normal 1 week after SPS exposure, there is a significant decrease in the expression of androgen receptor protein in lumbar segments 3 and 4 of the spinal cord. This might make the spinal center less responsive to androgens. In this report, I review findings on a recently identified spinal GRP systemthat could be vulnerable to stress and that controls male reproductive function. This system provides new insights into the clinical treatment of psychogenic erectile dysfunction triggered by stress and psychiatric disorders.

Original languageEnglish
Pages (from-to)519-526
Number of pages8
JournalJournal of Andrology
Volume31
Issue number6
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Gastrin-Releasing Peptide
Neurobiology
Erectile Dysfunction
Spinal Cord
Ejaculation
Major Depressive Disorder
Post-Traumatic Stress Disorders
Androgens
Reflex
Bombesin Receptors
Androgen Receptors
Psychiatry
Counseling
Animal Models
Pharmacology
Psychology
Proteins

Keywords

  • Ejaculation
  • Erection
  • Gastrin-releasing peptide
  • Lumbar spinal cord
  • Posttraumatic stress disorder
  • Testosterone

ASJC Scopus subject areas

  • Urology
  • Reproductive Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The neurobiology of psychogenic erectile dysfunction in the spinal cord. / Sakamoto, Hirotaka.

In: Journal of Andrology, Vol. 31, No. 6, 11.2010, p. 519-526.

Research output: Contribution to journalArticle

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