The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mamalian thioredoxin reductase is a selenoenzyme

T. Tamura, V. Gladyshev, S. Y. Liu, T. C. Stadtman

Research output: Contribution to journalReview article

29 Citations (Scopus)


The recent discovery that mammalian thioredoxin reductase is a selenoprotein furnishes an additional explanation of the mutual sparing roles of selenium and vitamin E in cellular antioxidant systems. Thioredoxin reductases isolated from human lung adenocarcinoma cells, human Jurkat T-cells and HeLa cells contain selenocysteine which is located in a C-terminal tripeptide, -Cys-SeCys-Gly.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
Issue number2
Publication statusPublished - Dec 1 1995
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

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