The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain

Xiao Hong Zhou, Oliver Brandau, Kang Feng, Toshitaka Oohashi, Yoshifumi Ninomiya, Uwe Rauch, Reinhard Fässler

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The mouse TEN-M/ODZ proteins belong to a new family of type II transmembrane proteins with unknown function. The family consists of four members, which are expressed highly in brain and less in many other tissues. In the present study we have generated specific RNA probes and antibodies to characterize the expression of the 4 Ten-m/Odz genes in the developing and adult central nervous system (CNS) of mice. Ten-m/Odz3 and Ten-m/Odz4 mRNAs were first detectable at E7.5, Ten-m/Odz2 expression started at the 37 somite (E 10.5) stage, while Ten-m/Odz1 mRNA is not found before E15.5. In the adult mouse CNS mRNAs of the 4 Ten-m/Odzs were expressed in distinct patterns, which partially overlapped. Immunostaining and in situ hybridization localized proteins and mRNAs of Ten-m/Odzs in adjacent areas suggesting that TEN-M/ODZ proteins might be transported from the cell body along the axon or that they are shed from the cell surface and diffuse into distant regions.

Original languageEnglish
Pages (from-to)397-405
Number of pages9
JournalGene Expression Patterns
Volume3
Issue number4
DOIs
Publication statusPublished - Aug 2003

Fingerprint

Messenger RNA
Brain
Genes
Proteins
Central Nervous System
Neurologic Mutant Mice
RNA Probes
Somites
In Situ Hybridization
Axons
Antibodies
Cell Body

Keywords

  • Brain
  • Central nervous system
  • Embryonic development
  • Expression
  • FGF8
  • Odz
  • Ten-m
  • Wnt-1

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain. / Zhou, Xiao Hong; Brandau, Oliver; Feng, Kang; Oohashi, Toshitaka; Ninomiya, Yoshifumi; Rauch, Uwe; Fässler, Reinhard.

In: Gene Expression Patterns, Vol. 3, No. 4, 08.2003, p. 397-405.

Research output: Contribution to journalArticle

Zhou, Xiao Hong ; Brandau, Oliver ; Feng, Kang ; Oohashi, Toshitaka ; Ninomiya, Yoshifumi ; Rauch, Uwe ; Fässler, Reinhard. / The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain. In: Gene Expression Patterns. 2003 ; Vol. 3, No. 4. pp. 397-405.
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