The Mohawk homeobox gene is a critical regulator of tendon differentiation

Yoshiaki Ito, Naoya Toriuchi, Teruhito Yoshitaka, Hiroe Ueno-Kudoh, Tempei Sato, Shigetoshi Yokoyama, Keiichiro Nishida, Takayuki Akimoto, Michiko Takahashi, Shigeru Miyaki, Hiroshi Asahara

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx-/- mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx-/- mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx-/- tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

Original languageEnglish
Pages (from-to)10538-10542
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number23
DOIs
Publication statusPublished - Jun 8 2010

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Homeobox Genes
Tendons
Collagen Type I
Tail
Collagen
Down-Regulation
Cell Count
Amino Acids

ASJC Scopus subject areas

  • General

Cite this

Ito, Y., Toriuchi, N., Yoshitaka, T., Ueno-Kudoh, H., Sato, T., Yokoyama, S., ... Asahara, H. (2010). The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proceedings of the National Academy of Sciences of the United States of America, 107(23), 10538-10542. https://doi.org/10.1073/pnas.1000525107

The Mohawk homeobox gene is a critical regulator of tendon differentiation. / Ito, Yoshiaki; Toriuchi, Naoya; Yoshitaka, Teruhito; Ueno-Kudoh, Hiroe; Sato, Tempei; Yokoyama, Shigetoshi; Nishida, Keiichiro; Akimoto, Takayuki; Takahashi, Michiko; Miyaki, Shigeru; Asahara, Hiroshi.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 23, 08.06.2010, p. 10538-10542.

Research output: Contribution to journalArticle

Ito, Y, Toriuchi, N, Yoshitaka, T, Ueno-Kudoh, H, Sato, T, Yokoyama, S, Nishida, K, Akimoto, T, Takahashi, M, Miyaki, S & Asahara, H 2010, 'The Mohawk homeobox gene is a critical regulator of tendon differentiation', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 23, pp. 10538-10542. https://doi.org/10.1073/pnas.1000525107
Ito, Yoshiaki ; Toriuchi, Naoya ; Yoshitaka, Teruhito ; Ueno-Kudoh, Hiroe ; Sato, Tempei ; Yokoyama, Shigetoshi ; Nishida, Keiichiro ; Akimoto, Takayuki ; Takahashi, Michiko ; Miyaki, Shigeru ; Asahara, Hiroshi. / The Mohawk homeobox gene is a critical regulator of tendon differentiation. In: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Vol. 107, No. 23. pp. 10538-10542.
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