The Mohawk homeobox gene is a critical regulator of tendon differentiation

Yoshiaki Ito, Naoya Toriuchi, Teruhito Yoshitaka, Hiroe Ueno-Kudoh, Tempei Sato, Shigetoshi Yokoyama, Keiichiro Nishida, Takayuki Akimoto, Michiko Takahashi, Shigeru Miyaki, Hiroshi Asahara

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Abstract

Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx-/- mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx-/- mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx-/- tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

Original languageEnglish
Pages (from-to)10538-10542
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number23
DOIs
Publication statusPublished - Jun 8 2010

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Cite this

Ito, Y., Toriuchi, N., Yoshitaka, T., Ueno-Kudoh, H., Sato, T., Yokoyama, S., Nishida, K., Akimoto, T., Takahashi, M., Miyaki, S., & Asahara, H. (2010). The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proceedings of the National Academy of Sciences of the United States of America, 107(23), 10538-10542. https://doi.org/10.1073/pnas.1000525107